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CLOFILIUM
SynDRA canonical compound SYN0000364 — structure-anchored drug synonym record
| Clinical phase | Phase 2 |
|---|
| Primary target(s) | KCNA5 | KCND2 | KCNH1 |
|---|
| Mechanism of action | potassium channel blocker |
|---|
All known targets
- KCNA5
- KCNH1
- KCND2
- KCNT1
- KCNT2
Mechanisms of action (all sources)
- KCNT1 ANTAGONIST
- KCNT2 ANTAGONIST
- KCNH1 MODULATOR
- KCNA5 MODULATOR
- potassium channel blocker
- KCNA5 BLOCKER (CHANNEL BLOCKER)
- KCNH1 BLOCKER (CHANNEL BLOCKER)
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- KCNH2
- ALOX15B
- ATAD5
- USP1
- TSHR
- TDP1
- SAMHD1
- PTH1R
- NFE2L2
- LMNA
- IDH1
- HTT
- HIF1A
- HDAC6
- GMNN
- GLP1R
- CYP3A4
- CYP2D6
- CYP2C9
- CYP2C19
- CYP1A2
- VDR
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACM1
- IDHC
- TP53
- SYK
- RARA
- PAX8
- NSD2
- NR5A2
- NF2L2
- MITF
- MDR1
- KSYK
- GPR32
- ACM4
- GLI3
- ESRRA
- ESR1
- CSTA
- CP3A7
- CP2D6
- CP19A
- COT2
- ATXN2
- ANDR
- TR10B
Drug classes
- Anti-Arrhythmia Agents
- Potassium Channel Blockers
Cross-references
Synonyms
- Clofilium cation
- Clofilium ion
- 4-(4-chlorophenyl)butyl-diethyl-heptylazanium
- UNII-847G178BMC
- 4-Chloro-N,N-diethyl-N-heptylbenzenebutanaminium
- AC1L1EHQ
- CHEMBL9484
- Benzenebutanaminium, 4-chloro-N,N-diethyl-N-heptyl-
- CHEBI:34649
- 847G178BMC
- MLS002154263
- GNF-Pf-3889
- SMR001233522
- Prestwick2_000319
- Prestwick3_000319
- Prestwick1_000319
- BSPBio_000318
- SCHEMBL157537
- SPBio_002537
- cid_175533
- GTPL2507
- BPBio1_000350
- DTXSID9048568
- CTK2F6670
- BDBM89440
- ZINC8035458
- NCGC00168464-02
- NCGC00168464-01
- 68379-03-3 (phosphate[1:1])
- LS-186732
- benzenebutanaminium, 4-chloro-n,n-diethyl-n-heptyl
- 4-(4-chlorophenyl)butyl-diethyl-heptyl-ammonium
- (4-(P-CHLOROPHENYL)BUTYL)DIETHYLHEPTYLAMMONIUM
- RefChem:127040
- DTXCID2028197
- N-(4-(4-Chlorophenyl)butyl)-N,N-diethylheptan-1-aminium
- N-[4-(4-chlorophenyl)butyl]-N,N-diethylheptan-1-aminium
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