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GLYBURIDE
SynDRA canonical compound SYN0000363 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ABCC8 |
|---|
| Mechanism of action | Insulin secretagogue |
|---|
| Indication | diabetes mellitus | hyperglycemia |
|---|
| Disease area | endocrinology |
|---|
All known targets
- ABCC8
- KCNJ11
- CFTR
- KCNJ8
- ABCC9
- SLCO2B1
- ABCB11
- KCNJ5
- ABCA1
- TRPA1
- PPARG
- Nlrp3
Mechanisms of action (all sources)
- ATP channel blocker
- Insulin secretagogue
- KCNJ11 BLOCKER
- Sulfonylurea receptor 1, Kir6.2 blocker
- ABCC8 BLOCKER
- CFTR PORE BLOCKER
- KCNJ8 MODULATOR
- KCNJ11 MODULATOR
- SLCO2B1 INHIBITOR
- ABCC8 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I2
- SLCO1B1
- ABCB1
- MMP1
- MAPT
- MC3R
- MC4R
- MC5R
- MLNR
- MMP9
- MAPK14
- NFE2L2
- NPY1R
- NPY2R
- NR3C1
- OPRD1
- MAPK3
- MAPK1
- OPRM1
- MAOB
- MAOA
- LMNA
- LCK
- KCNK9
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HSPA5
- HRH3
- HRH2
- OPRK1
- PDE3A
- HMGCR
- PDE4D
- USP1
- TSHR
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- CP3A7
- KCMB1
- KCMB4
- MDR1
- NUDT15
- SURF1
Drug classes
- Hypoglycemic Agents
- Sulfonylurea
ATC classes
- A10B · BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Cross-references
Synonyms
- DIABETA
- GLUCOVANCE
- GLYBURIDE (MICRONIZED)
- GLYBURIDE AND METFORMIN HYDROCHLORIDE
- GLYNASE
- Glynase
- MICRONASE
- glibenclamide
- glicuformine
- GLIBENCLAMIDE
- GLIBENCLAMIDA
- CIRARA
- GLIBENCLAMIDUM
- GLYBENCLAMIDE
- Amglidia
- Calabren
- Daonil
- Diabeta
- Diabetamide 2.5
- Diabetamide 5
- Euglucon
- Gliken
- GLYBURIDE (GLIBENCLAMIDE)
- Glyburide (micronized)
- Glyburide component of glucovance
- GLYBURIDE10238-21-8
- HB-419
- Lederglib
- Libanil
- Malix
- Micronase
- NSC-759618
- Semi-daonil
- U-26,45
- U-26,452
- U-26452
- Glibenclamide
Reported adverse events
- Lactic acid
- Lactic acidosis
- Leukopenia
- Porphyria
- Headache
- Nausea
- Dizziness
- Abdominal pain
- Angioedema
- Vitamin B12
- Vitamin B1
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