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KETOROLAC
SynDRA canonical compound SYN0000332 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | PTGS2 |
|---|
| Mechanism of action | Cyclooxygenase inhibitor |
|---|
| Indication | pain relief |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- PTGS1
- PTGS2
- Akr1b1
- Fabp1
- PAK1
- Ptgds
Mechanisms of action (all sources)
- Cyclooxygenase inhibitor
- PTGS2 INHIBITOR
- PTGS1 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCC4
- OPRM1
- HTT
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KCNH2
- HTR6
- NPC1
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- GMNN
- GHSR
- MMP9
- NPY1R
- ACHE
- NPY2R
- TRPV1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLCO1B3
- SLC6A4
- SLC6A3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CASP3
- CASP4
- CASP5
- CASP9
- CDC42
- FABP2
- HDAC9
- RAC1
- RARA
Drug classes
- Cyclooxygenase Inhibitors
- Nonsteroidal Anti-inflammatory Drug
- Cyclooxygenase Inhibitor
- Analgesics
- Analgesics, Non-Narcotic
- Anti-Inflammatory Agents
- Anti-Inflammatory Agents, Non-Steroidal
- Antirheumatic Agents
- Enzyme Inhibitors
- Peripheral Nervous System Agents
- Sensory System Agents
ATC classes
- S01B · ANTIINFLAMMATORY AGENTS
- M01A · ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
- MYDRIATICS AND CYCLOPLEGICS
Cross-references
Synonyms
- ACULAR
- ACULAR LS
- ACULAR PRESERVATIVE FREE
- ACUVAIL
- Acular
- Acuvail
- KETOROLAC TROMETHAMINE
- KETOROLAC TROMETHAMINE AND PHENYLEPHRINE HYDROCHLORIDE
- OMIDRIA
- Omidria
- SPRIX
- Sprix
- ketorolac tromethamine
- ketorolac trometamol
- trometamol ketorolac
- (+/-)-Ketorolac
- keromin
- Ketorolaco
- Ketoralac
- Ketorolacum
- Macril
- Ketorolaco [Spanish]
- Ketorolacum [Latin]
- RS-37619
- Acular (TN)
- Ketorolac (INN)
- Ketorolac [INN:BAN]
- Toradol (TN)
- (+-)-Ketorolac
- (+-)-isomer
- YZI5105V0L
- rac Ketorolac
- CHEBI:6129
- RefChem:55433
- DTXCID503189
- M01AB15
- S01BC05
- MFCD00864281
Reported adverse events
- Bleeding
- GI bleed
- Ulceration
- Elderly
- Crohn's disease
- Stevens-Johnson syndrome
- Rash
- Hypersensitivity
- Hypertension
- Headache
- Nausea
- Constipation
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