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ISONIAZID

SynDRA canonical compound SYN0000326 — structure-anchored drug synonym record

All known targets

• CYP3A4
• CYP1A2
• CYP2C19
• CYP2C8
• CYP2E1
• Bact inhA
• CYP3A5
• MPO
• folA
• inhA
• katG

Mechanisms of action (all sources)

• Cyclooxygenase inhibitor
• Enoyl-acyl-carrier protein reductase inhibitor
• FABI inhibitor
• Bact inhA INHIBITOR
• inhA INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• ABCB1
• KDM4E
• NPY1R
• NEIL1
• MMP9
• MMP1
• MLNR
• MC5R
• MC4R
• MC3R
• MAPK3
• MAPK14
• MAPK1
• MAOA
• LCK
• KCNH2
• NR1I2
• KAT2A
• HTR7
• HTR6
• HTR3A
• HTR2C
• HTR2B
• HTR2A
• HTR1A
• HRH3
• HRH2
• HRH1
• HMGCR
• HDAC6
• NPY2R
• NR3C1
• GLS
• PTPRC
• TBXAS1
• TBXA2R
• TACR2
• TACR1
• SLCO2B1
• SLCO1B3

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• AHR
• CP1A2
• CP2C9
• CP2CJ
• CP2D6
• CP3A4
• MDR1
• RARA

Drug classes

• Antimycobacterial
• Anti-Bacterial Agents
• Anti-Infective Agents
• Antimetabolites
• Antitubercular Agents
• Fatty Acid Synthesis Inhibitors
• Hypolipidemic Agents

ATC classes

• J04A · DRUGS FOR TREATMENT OF TUBERCULOSIS

Cross-references

• PubChem CID: 3767
• ChEMBL: CHEMBL64
• DrugBank: DB00951
• ChEBI: CHEBI:6030
• KEGG: D00346
• RxNorm: 6038
• PDB: NIZ
• Wikipedia: Isoniazid
• TTD: D09XQF
• LINCS BRD: BRD-K87202646

Synonyms

• DOW-ISONIAZID
• HYZYD
• INH
• LANIAZID
• NYDRAZID
• RIFAMATE
• RIFAMPIN AND ISONIAZID
• RIFATER
• RIMIFON
• STANOZIDE
• 4-Pyridinecarboxylic hydrazide
• armazid
• isoniazide
• isonicotinohydrazide
• Isoniazide
• Isoniazida
• Armazid
• Armazide
• Atcotibine
• Cedin
• Cotinazin
• Dianicotyl
• Eralon
• Ertuban
• Hidrasonil
• Hydrazid
• Ipcazide
• Iscotin
• Isidrina
• Isobicina
• Isoniazidum
• Isonicotan
• Mybasan
• Neumandin
• Teebaconin
• Tisiodrazida
• NSC-9659

Reported adverse events

• Nausea
• Agranulocytosis
• Hypersensitivity
• Cerebellar syndrome
• Stevens-Johnson syndrome