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ROLIPRAM
SynDRA canonical compound SYN0000321 — structure-anchored drug synonym record
| Clinical phase | Phase 3 |
|---|
| Primary target(s) | PDE4D |
|---|
| Mechanism of action | Phosphodiesterase inhibitor |
|---|
All known targets
- PDE4A
- PDE4B
- PDE4D
- PDE4C
- PDE5A
Mechanisms of action (all sources)
- Phosphodiesterase inhibitor
- PDE4A INHIBITOR
- Phosphodiesterase 4 inhibitor
- PDE4D INHIBITOR
- PDE4B INHIBITOR
- PDE4C INHIBITOR
- PDE5A INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- TNF
- PDE3A
- PDE3B
- ADRB2
- PDE7A
- PDE1B
- PDE1C
- PDE2A
- PDE6C
- PDE7B
- PDE11A
- PDE8A
- PDE8B
- PDE9A
- POLI
- TDP1
- PDE1A
- PDE10A
- ALB
- CYP3A4
- APEX1
- APP
- ARSA
- BLM
- CBX1
- CNR1
- EPHX2
- MAPK1
- FEN1
- GLP1R
- HDAC6
- IDH1
- KDM4E
- KMT2A
- USP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CFTR
- CP1A2
- DRD1
- DRD2
- GLI3
- KCMB4
- KSYK
- SYK
- YAP1
Drug classes
- Antidepressive Agents
- Phosphodiesterase 4 Inhibitors
Cross-references
Synonyms
- (r,s)-rolipram
- NSC-760125
- SB-95952
- ZK 62 711
- ZK-62711
- ZK-62771
- Rolipramum
- Rolipramum [Latin]
- 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
- Adeo
- Rolipram [USAN:INN]
- 4-[3-(cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
- 4-(3-(cyclopentyloxy)-4-methoxyphenyl)pyrrolidin-2-one
- 4-(3-(Cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinone
- (R,S)-rolipram
- CHEMBL63
- EINECS 262-771-1
- BRN 1588548
- MLS000069691
- CHEBI:104872
- HJORMJIFDVBMOB-UHFFFAOYSA-N
- 4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidone
- [3H]rolipram
- NSC 760125
- SB 95952
- K676NL63N7
- (+-)-rolipram
- Pyrrolidone, 4-(3-cyclopentyloxy-4-methoxyphenyl)-2-
- ZK62711
- RefChem:389268
- (+/-)-Rolipram
- 4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
- MFCD00270906
- 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-
- s1430
- 4-[3-(cyclopentoxy)-4-methoxy-phenyl]pyrrolidin-2-one
- SMR000058510
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