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NEVIRAPINE
SynDRA canonical compound SYN0000293 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP3A5 |
|---|
| Mechanism of action | Reverse transcriptase inhibitor |
|---|
| Indication | human immunodeficiency virus (HIV-1) |
|---|
| Disease area | infectious disease |
|---|
All known targets
- CYP1A2
- CYP2A6
- CYP2B6
- CYP2C9
- CYP2D6
- CYP3A4
- CYP3A5
- CYP2C19
- HIV RT
- gag-pol
- pol
- reverse transcriptas
Mechanisms of action (all sources)
- reverse transcriptase inhibitor
- non-nucleoside reverse transcriptase inhibitor
- HIV RT MODULATOR
- pol INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PDE3A
- ADORA3
- ABCB1
- LCK
- NPY1R
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- KCNH2
- NR3C1
- HTR7
- HTR6
- HTR5A
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- NPY2R
- OPRD1
- NTSR1
- GIPR
- USP1
- TDP1
- TBXAS1
- TBXA2R
- TACR2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP1A2
- CP2D6
- CP3A4
- EPHA2
- RXRA
Drug classes
- Non-Nucleoside Reverse Transcriptase Inhibitors
- Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor
- Cytochrome P450 2B6 Inducers
- Cytochrome P450 3A Inducers
- Anti-HIV Agents
- Anti-Infective Agents
- Anti-Retroviral Agents
- Antiviral Agents
- Cytochrome P-450 CYP3A Inducers
- Enzyme Inhibitors
- Metabolic Side Effects of Drugs and Substances
- Nucleic Acid Synthesis Inhibitors
ATC classes
- J05A · DIRECT ACTING ANTIVIRALS
Cross-references
Synonyms
- LAMIVUDINE, NEVIRAPINE AND ZIDOVUDINE
- VIRAMUNE
- VIRAMUNE XR
- Viramune
- nevirapine hemihydrate
- viramune
- nevarapine
- Nevirapina
- Nevirapine teva
- Nevirapine, anhydrous
- Nevirapinum anhydrous
- BIRG-0587
- BIRG0587
- NSC-641530
- Viramune xr
- Nevirapine anhydrous
- NEV
- NVP
- Cahill May Roberts Brand of Nevirapine
- Promeco Brand of Nevirapine
- BI-RG-587
- BIRG-587
- BIRG587
- NON-NUCLEOSIDE RT INHIBITOR NEVIRAPINE
- Nevirapine & PRO 140
- Nevirapine [USAN:INN]
- Viramune (TN)
- Viramune(TM)
- Nevirapine & CD4-IgG
- Nevirapine (JAN/USP/INN)
- Viramune, BI-RG 587, Nevirapine
- BI-RG-587 & CD4-IgG
- nevirapine (usp impurity)
- NSC 641530
- nevirapine anhydrous (usp-rs)
- nevirapine (ep monograph)
- nevirapine (usp monograph)
Reported adverse events
- Hepatic failure
- Stevens-Johnson syndrome
- Fe
- TEN
- Rash
- Abdominal pain
- Fatigue
- Granulocytopenia
- Headache
- Hepatitis
- Myalgia
- Nausea
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