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ETRETINATE
SynDRA canonical compound SYN0000287 — structure-anchored drug synonym record
| Clinical phase | Withdrawn |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | RARA | RXRG |
|---|
| Mechanism of action | protein synthesis inhibitor |
|---|
All known targets
- RARA
- RXRG
- RARB
- RARG
- RXRA
- RXRB
- RBP1
- STAT3
- ABCB11
- Abcb11
Mechanisms of action (all sources)
- RXRB AGONIST
- Retinoid receptor agonist
- RARG AGONIST
- RXRG AGONIST
- RARB AGONIST
- RARA AGONIST
- RXRA AGONIST
- protein synthesis inhibitor
- STAT3 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- ADORA1
- OPRD1
- HTR2B
- HTR2C
- HTR3A
- KCNH2
- MAOA
- MC3R
- MC4R
- MLNR
- NPY1R
- NR1I2
- NR3C1
- OPRK1
- HTR1A
- OPRM1
- PDE3A
- PDE4D
- PGR
- PTGS2
- SAMHD1
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- TBXA2R
- TDP1
- HTR2A
- HRH2
- ADORA2A
- CCKAR
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ANDR
- ATF6
- CP1A2
- CP2C9
- CP2CJ
- CP3A7
- ESRRA
- GEMI
- HIF1A
- HSPB1
- PRGR
- TP53
Drug classes
- Dermatologic Agents
- Keratolytic Agents
- Retinoid
ATC classes
- D05B · ANTIPSORIATICS FOR SYSTEMIC USE
Cross-references
Synonyms
- TEGISON
- ethyl etrinoate
- tegison
- tigasone
- Etretinato
- Acitretin related compound b
- Ethyl etrinoate
- NSC-297936
- RO-10-9359
- RO-109359
- Tegison
- Tigason
- Retinoid
- Etretinatum
- Ro-10-9359
- Etretinatum [INN-Latin]
- Etretinato [INN-Spanish]
- UNII-65M2UDR9AG
- CCRIS 3615
- HSDB 7185
- EINECS 259-119-3
- NSC 297936
- 65M2UDR9AG
- CHEBI:4913
- C23H30O3
- Ro 10 9359
- Ro 109359
- DTXCID603036
- NSC297936
- Tigazon
- Etrinoate, Ethyl
- Ro109359
- RefChem:57004
- B109359
- B10 9359
- D05BB01
- MFCD00866624
- NCGC00167500-01
Reported adverse events
- GI malformation
- Hepatotoxicity
- Dysphonia
- Arthralgia
- Cheilitis
- Dizziness
- Dry mouth
- Flushing
- Headache
- Jaundice
- Stomatitis
- Conjunctivitis
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