← SynDRA
GYKI-52466
SynDRA canonical compound SYN0000285 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | GRIA1 |
|---|
| Mechanism of action | Glutamate receptor antagonist |
|---|
All known targets
Mechanisms of action (all sources)
- Kainate receptor antagonist
- Glutamate receptor antagonist
- GRIA1 ANTAGONIST
- GRIA2 ANTAGONIST
- GRIA3 ANTAGONIST
- GRIA4 ANTAGONIST
- GRIA1 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ALDH1A1
- APEX1
- TDP1
- RAPGEF4
- RAPGEF3
- POLI
- PIN1
- OPRM1
- NFKB1
- MAPT
- LMNA
- KDM4A
- KCNH2
- HIF1A
- HDAC6
- EHMT2
- CYP3A4
- CYP2D6
- CYP2C9
- CYP2C19
- CYP1A2
- BAZ2B
- ARSA
- USP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ADCY9
- CP1A2
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- CP3A7
- DRD2
- NTM1A
- RPGF4
- TP53
Drug classes
- Anticonvulsants
- Excitatory Amino Acid Antagonists
- Muscle Relaxants, Central
- Neuroprotective Agents
Cross-references
Synonyms
- GYKI 52466
- UNII-471V8NZ5X3
- GYKI 52466 HCl
- CHEMBL275006
- CHEBI:79560
- 471V8NZ5X3
- 1-(p-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride
- 4-(8-methyl-9h-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl)aniline
- 4-(8-Methyl-9H-1,3-dioxolo(4,5-h)(2,3)benzodiazepin-5-yl)benzenamine
- Benzenamine,4-(8-methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-
- Benzenamine, 4-(8-methyl-9H-1,3-dioxolo(4,5-h)(2,3)benzodiazepin-5-yl)-
- C17H15N3O2
- RefChem:783294
- DTXCID8067991
- GYKI-2466
- GYKI52466
- A1AB5
- LFBZZHVSGAHQPP-UHFFFAOYSA-N
- Tocris-1454
- Lopac-G-119
- Lopac0_000631
- SCHEMBL194854
- GTPL4210
- orb1705052
- SCHEMBL29357520
- GYKI53784
- GLXC-05139
- BDBM50048389
- HB0311
- PDSP1_001843
- PDSP2_001826
- AKOS030582785
- CCG-204719
- SDCCGSBI-0050612.P002
- NCGC00015463-01
- NCGC00015463-02
- NCGC00015463-03
- NCGC00015463-04
- NCGC00015463-08
Look up GYKI-52466 in the interactive SynDRA portal →