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PENTAMIDINE
SynDRA canonical compound SYN0000274 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | TRDMT1 |
|---|
| Mechanism of action | anti-pneumocystis agent |
|---|
| Indication | pneumonia |
|---|
| Disease area | infectious disease |
|---|
All known targets
- ACR
- SAT1
- PLG
- PRMT1
- PRSS1
- PTP4A1
- PTP4A2
- PTP4A3
- S100B
- S100b
- SLC22A1
- KCNH2
Mechanisms of action (all sources)
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- CYP2D6
- TMPRSS2
- SLC6A4
- OPRM1
- F2
- ESR1
- DRD1
- HRH3
- AGTR2
- NFE2L2
- PKM
- PGR
- PDE5A
- PDE4A
- PDE3A
- ADRA2B
- OPRK1
- OPRD1
- NR3C1
- NR1H4
- NPY2R
- NPY1R
- NPC1
- MTOR
- IDH1
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MAPT
- MAPK3
- MAPK14
- MAPK1
- LMNA
- LCK
- KDR
- KDM4E
- PMP22
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ACES
- SYK
- RARA
- PAX8
- NSD2
- NR1I2
- NF2L2
- MRGPRX1
- MDR1
- M4K2
- M3K3
- KSYK
- JAK2
- HDAC9
- HDAC3
- GLI3
- ESRRA
- DPOLB
- CP2D6
- CP19A
- ANDR
- ACP1
- ACM4
- ACM1
- YAP1
Drug classes
- Antiprotozoal
- Anti-Infective Agents
- Antifungal Agents
- Antiparasitic Agents
- Antiprotozoal Agents
- Trypanocidal Agents
- anti-pneumocystis agent
ATC classes
- P01C · AGENTS AGAINST LEISHMANIASIS AND TRYPANOSOMIASIS
Cross-references
Synonyms
- NEBUPENT
- NebuPent
- PENTACARINAT
- PENTAM
- PENTAMIDINE ISETHIONATE
- Pentam
- pentamidine isetionate
- pentamidine diisethionate
- pentamidine isethionate
- pentamidin
- pentamidine mesylate
- pentamidine mesilate
- Pentamidina
- Mp-601205
- Pentam 300
- GNF-Pf-3680
- MB-800 FREE BASE
- MB 800
- MB-800 (AS ISETHIONATE)
- NSC-9921
- RP-2512 FREE BASE
- RP 2512
- Pentacarinat
- Lomidine
- Nebupent
- PNT
- Pentamide
- Pentamidin
- Pentamidinum
- Pneumopent
- Pentamidina [DCIT]
- Pentamidine isetionate
- Pentamidine mesylate
- MB-800
- Lomidine (TN)
- Nebupent (as isethionate)
- Pentacarinat (as isethionate)
- Pentam 300 (as isethionate)
Reported adverse events
- Anxiety
- Asthma
- Blepharitis
- Flank pain
- Dizziness
- Hypotension
- Nausea
- Rash
- Stevens-Johnson syndrome
- Abdominal pain
- Arthralgia
- Bronchitis
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