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HALOPERIDOL
SynDRA canonical compound SYN0000269 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HTR2A |
|---|
| Mechanism of action | Dopamine receptor antagonist |
|---|
| Indication | schizophrenia | Tourette's disorder |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- DRD3
- DRD4
- HTR2A
- DRD1
- HTR1A
- HTR7
- DRD5
- KCNH1
- HTR2B
- HRH1
- HTR1D
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- DRD2 INVERSE AGONIST
- D2-like dopamine receptor inverse agonist
- DRD3 INVERSE AGONIST
- DRD4 INVERSE AGONIST
- HTR1A ANTAGONIST
- HTR1D ANTAGONIST
- HTR2B ANTAGONIST
- HTR7 ANTAGONIST
- DRD1 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- NR1I2
- HLA-A
- TACR1
- CYP2C19
- PTGS2
- ESR1
- CYP2D6
- SCN5A
- CACNA1C
- CYP2J2
- SLC6A3
- CYP3A4
- PDE4A
- NTSR1
- PDE3A
- ABCB11
- NR3C1
- PDE5A
- PDE6A
- PGR
- PLAUR
- PDE4D
- NPY2R
- PPARG
- NPY1R
- KDR
- LCK
- MAOA
- MAPK1
- MAPK14
- MAPK3
- MC3R
- MC4R
- MC5R
- MLNR
- MMP1
- MMP9
- MTOR
- NFE2L2
- NFKB1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- 5HT1D
- SCN8A
- SCN7A
- SCN4A
- SCN11A
- SCN10A
- RARA
- PRGR
- NSD2
- KCMB2
- KCMB1
- KCMA1
- IL1B
- GLI3
- GEMI
- ESRRA
- CP3A4
- CP2D6
- CASP7
- CASP3
- CACNA1S
- CACNA1F
- CACNA1D
- ANDR
- ACM4
- ACM1
- 5HT7R
- 5HT2B
- SCN9A
Drug classes
- Anti-Dyskinesia Agents
- Antiemetics
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Gastrointestinal Agents
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Psychotropic Drugs
- Tranquilizing Agents
ATC classes
Cross-references
Synonyms
- HALDOL
- HALDOL SOLUTAB
- HALOPERIDOL INTENSOL
- HALOPERIDOL LACTATE
- Haldol
- aloperidin
- haloperin
- sigaperidol
- haloperidol lactate
- MCN-JR-1625
- NSC-170973
- NSC-615296
- R-1625
- Dolpin
- Dozic
- Fortunan
- Haldol solutab
- Haloperidol component of vesalium
- Kentace
- Keselen
- Serenace
- Haloperidol decanoate impurity, haloperidol-
- Aldo
- Aloperidin
- Aloperidol
- Aloperidolo
- Aloperidon
- Bioperidolo
- Brotopon
- Dozix
- Eukystol
- Galoperidol
- Halidol
- Halojust
- Halol
- Halopal
- Haloperido
Reported adverse events
- Dystonia
- Agranulocytosis
- Neuroleptic malignant syndrome
- Tachycardia
- Tardive dyskinesia
- Insomnia
- Dyskinesia
- Dry mouth
- Laryngospasm
- Cataract
- Akinesia
- Jaundice
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