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BUSPIRONE
SynDRA canonical compound SYN0000251 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HTR1A |
|---|
| Mechanism of action | Serotonin receptor agonist |
|---|
| Indication | generalized anxiety disorder (GAD) |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- HTR1A
- DRD2
- HTR2A
- HTR2C
- HTR7
- Htr1a
- Htr1b
- Htr1d
- Htr1f
- Htr2a
- Htr2b
- Htr2c
Mechanisms of action (all sources)
- Serotonin receptor agonist
- HTR1A PARTIAL AGONIST
- Serotonin 1a (5-HT1a) receptor partial agonist
- HTR1A AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- ABCB1
- MAPK14
- NPY2R
- NPY1R
- NFE2L2
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MBNL1
- MAPK3
- MAPK1
- GNAS
- MAOA
- LCK
- KDM4E
- IDH1
- HTR6
- HTR3A
- HRH3
- HRH2
- HRH1
- HMGCR
- HIF1A
- NR3C1
- OPRD1
- OPRK1
- SAMHD1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ANDR
- CP2D6
- CP3A7
- ESRRA
- GLI3
- KAPCB
- KIFAP3
- KSYK
- MDR1
- NF2L2
- NR1I2
- SYK
Drug classes
- Anti-Anxiety Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Neurotransmitter Agents
- Psychotropic Drugs
- Serotonin Agents
- Serotonin Receptor Agonists
- Tranquilizing Agents
ATC classes
Cross-references
Synonyms
- BUCAPSOL
- BUSPAR
- BUSPIRONE HYDROCHLORIDE
- Bucapsol
- Buspar
- buspin
- buspirone hydrochloride
- buspirone HCl
- Buspirona
- Gen-buspirone
- BCI-024
- Ansial
- Ansiced
- Anxiron
- Axoren
- Bespar
- Buspironum
- Buspisal
- Ansial (TN)
- Ansiced (TN)
- Anxiron (TN)
- Axoren (TN)
- Bespar (TN)
- BuSpar (TN)
- Buspimen (TN)
- Buspinol (TN)
- Buspiron (TN)
- Buspirona [INN-Spanish]
- Buspirone (INN)
- Buspirone [INN:BAN]
- Buspirone-MDTS
- Buspironum [INN-Latin]
- Buspisal (TN)
- Gen-Buspirone
- Narol (TN)
- Sorbon (TN)
- Spamilan (TN)
- Spitomin (TN)
Reported adverse events
- Dizziness
- Anger
- Depression
- Hostility
- Insomnia
- Nausea
- Palpitations
- Constipation
- Fatigue
- Headache
- Tremor
- Nervousness
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