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AMSACRINE
SynDRA canonical compound SYN0000202 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | TOP2A |
|---|
| Mechanism of action | Topoisomerase inhibitor |
|---|
| Indication | acute lymphoblastic leukemia (ALL) |
|---|
| Disease area | hematologic malignancy |
|---|
All known targets
- TOP2A
- TOP2B
- KCNH2
- CYP2D6
- SLC22A1
- TOP1
- TOP1MT
Mechanisms of action (all sources)
- topoisomerase inhibitor
- TOP2A INHIBITOR
- DNA topoisomerase II inhibitor
- TOP2B INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR3A
- AOX1
- DRD1
- DRD2
- OPRK1
- CHRM3
- CHRM1
- PTGS2
- NPY1R
- BDKRB2
- PDE4D
- ADRA2C
- KDM1A
- ABCC4
- ADRA2B
- HRH1
- LMNA
- IDH1
- KDM4A
- OPRD1
- KDM4E
- NR3C1
- NR1I2
- NPSR1
- MAOA
- NFE2L2
- MTOR
- MPHOSPH8
- OPRM1
- MC3R
- MBNL1
- MAPT
- KMT2A
- MLNR
- ABCB1
- PDE3A
- PGR
- USP1
- TSHR
- TP53
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ALR
- IL1B
- SC5A7
- PPARG
- PAX8
- NTM1A
- NSD2
- NR5A2
- NCOA3
- NCOA1
- MRGPRX1
- MITF
- MDR1
- MDM4
- MDM2
- KSYK
- IFNB1
- ANDR
- IDHC
- HLAB
- GPX4
- GPX1
- GLSK
- GEMI
- ESRRA
- EPAS1
- CSTA
- CP1A2
- CP19A
- BRCA1
- BARD1
- ATRX
- SYK
Drug classes
- Antineoplastic Agents
- Indicators and Reagents
- Intercalating Agents
ATC classes
- L01X · OTHER ANTINEOPLASTIC AGENTS
Cross-references
Synonyms
- acridinylanisidide
- amekrin
- amsidil
- amsidine
- amsidyl
- lamasine
- Amsacrina
- Acridinylanisidide
- Amekrin
- Amsidil
- Amsidine
- Lamasine
- CI-880
- M-AMSA
- NCI-249992
- NSC-156303
- NSC-249992
- SN-11841
- SN-21429
- Amsidyl
- Amecrin
- Amsacrinum
- Amsine
- MAMSA
- NAMSA
- Acridinyl Anisidide
- SN 21429
- SN11841
- AMSA P-D
- Acridinyl anisidide (TN)
- Amsacrina [INN-Spanish]
- Amsacrinum [INN-Latin]
- Amsidyl (TN)
- Cain's Acridine
- Meta-AMSA
- Meta-Amsacrine
- Amsacrine (USAN/INN)
- Amsacrine [USAN:BAN:INN]
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