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QUINACRINE
SynDRA canonical compound SYN0000182 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Primary target(s) | TP53 |
|---|
| Mechanism of action | Cytokine production inhibitor |
|---|
| Indication | giardiasis |
|---|
| Disease area | infectious disease |
|---|
All known targets
- PLA2G1B
- TP53
- ACHE
- SCN1A
- PLA2G2D
- PRNP
- PTGS1
- PTGS2
- Pla2g1b
- Prnp
- SCN2A
- SCN3A
Mechanisms of action (all sources)
- TP53 ACTIVATOR
- NFKB pathway inhibitor
- Cytokine production inhibitor
- PLA2G1B INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- KCNH2
- OPRM1
- ESR1
- NSD1
- HRH3
- HTR1A
- CGAS
- DRD1
- ORM2
- OPRK1
- NFE2L2
- OPRD1
- PDE3A
- NR3C1
- NPY2R
- PDE4A
- NPY1R
- NPSR1
- NPC1
- MPHOSPH8
- PGR
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MBNL1
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KMT2A
- PDE5A
- ABCB1
- KDR
- TDP1
- SLCO1B3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- PEBB
- MDR1
- NF2L2
- NNMT
- NR1H4
- NR1I2
- NSD2
- NTM1A
- NTMT1
- PNMT
- ACES
- RAPGEF3
- RAPGEF4
- RARA
- RPGF3
- RPGF4
- RUNX1
- STK33
- SYK
- KSYK
- IFNG
- HNMT
- HDAC9
- AHR
- ANDR
- CASP3
- CCDC88A
- CFTR
- CIB1
- COMT
- CP1A2
- CP2D6
- CP3A4
- CP3A7
- CREB1
- DPOLB
- ESRRA
- GAMT
- GLI3
Drug classes
- Anthelmintics
- Anti-Infective Agents
- Anticestodal Agents
- Antimalarials
- Antinematodal Agents
- Antineoplastic Agents
- Antiparasitic Agents
- Antiplatyhelmintic Agents
- Antiprotozoal Agents
- Enzyme Inhibitors
ATC classes
- P01A · AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES
Cross-references
Synonyms
- mepacrine
- quinacrin
- atabrine
- acrinamine
- acriquine
- quinacrine dihydrochloride hydrate
- quinacrine dihydrochloride
- quinacrine hydrochloride
- quinacrine HCl
- Mepacrine
- Mepacrina
- Atabrine
- GNF-Pf-5448
- Acrinamine
- Acriquine
- Quinactine
- Antimalarina
- Haffkinine
- Akrichin
- Italchine
- acrichine
- Erion
- Mepacrinum
- Quinacrine hydrochloride
- Mepacrine [INN:BAN]
- St 439
- Mepacrinum [INN-Latin]
- Mepacrina [INN-Spanish]
- atebrin
- Malaricida
- Methoquine
- Palacrin
- Italchin
- Pentilen
- Palusan
- Atebrine
- Metochin
- Mecryl
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