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PENTOBARBITAL
SynDRA canonical compound SYN0000181 — structure-anchored drug synonym record
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | GABRQ |
|---|
| Mechanism of action | Barbiturate antiepileptic |
|---|
All known targets
- GABRA1
- GABRB2
- GABRA2
- GABRB3
- GABRG2
- GABRA6
- GABRG1
- GABRA3
- GABRQ
- GABRB1
- GABRG3
- GABRP
Mechanisms of action (all sources)
- GABA receptor modulator
- GABRA1 POSITIVE ALLOSTERIC MODULATOR
- GABRB2 POSITIVE ALLOSTERIC MODULATOR
- GABRG2 POSITIVE ALLOSTERIC MODULATOR
- GABRB3 POSITIVE ALLOSTERIC MODULATOR
- GABRA4 POSITIVE ALLOSTERIC MODULATOR
- GABRG3 POSITIVE ALLOSTERIC MODULATOR
- GABRQ POSITIVE ALLOSTERIC MODULATOR
- GABRA3 POSITIVE ALLOSTERIC MODULATOR
- GABRP POSITIVE ALLOSTERIC MODULATOR
- GABRD POSITIVE ALLOSTERIC MODULATOR
- GABRG1 POSITIVE ALLOSTERIC MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADORA1
- OPRD1
- HTR2C
- HTR3A
- KCNK9
- KDM4E
- MAOA
- MC3R
- MC4R
- MLNR
- MMP14
- NPY1R
- NR1I2
- NR3C1
- OPRK1
- HTR2A
- OPRM1
- PDE3A
- PDE4D
- PGR
- PTGS2
- SAMHD1
- SLC29A1
- SLC6A2
- SLC6A3
- SLC6A4
- SLCO1B1
- SLCO1B3
- HTR2B
- HTR1A
- ADORA2A
- CCKAR
- ADORA3
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRB1
- ADRB2
- AGTR1
Drug classes
- Adjuvants, Anesthesia
- Central Nervous System Agents
- Central Nervous System Depressants
- GABA Agents
- GABA Modulators
- Hypnotics and Sedatives
- Neurotransmitter Agents
- Barbiturate antiepileptic
ATC classes
- N05C · HYPNOTICS AND SEDATIVES
Cross-references
Synonyms
- NEMBUTAL
- NEMBUTAL SODIUM
- Nembutal
- PENTOBARBITAL SODIUM
- Pentobarsol
- SODIUM PENTOBARBITAL
- pentobarbital calcium
- ethaminal
- mebubarbital
- nembutal
- neodorm
- pentabarbitone
- pentobarbitone
- pentobarbituric acid
- phetobarbitone
- pentobarbital sodium
- sodium pentobarbital
- Pentobarbitone
- NSC-28708
- Pentobarbital cii
- Aethaminalum
- Dorsital
- Etaminal
- Ethaminal
- Mebubarbital
- Mebumal
- Nebralin
- Neodorm
- Pentabarbital
- Pentabarbitone
- Pentobarbitale
- Pentobarbitalum
- Pentobarbiturate
- Rivadorm
- Pentobarbital calcium
- Pentobarbital suppository dosage form
- Pentobarbitale [DCIT]
- Pentobarbituric acid
Reported adverse events
- Agitation
- Bradycardia
- Headache
- Hypoventilation
- Nausea
- Somnolence
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