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NORTRIPTYLINE
SynDRA canonical compound SYN0000177 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SLC6A4 |
|---|
| Mechanism of action | Tricyclic antidepressant |
|---|
| Indication | depression |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SLC6A4
- SLC6A2
- KCNJ10
- ADRA1A
- ADRA2B
- CHRM3
- HTR2A
- HTR1A
- HRH1
- ADRA2C
- DRD2
- CYP2C19
Mechanisms of action (all sources)
- SLC6A4 INHIBITOR
- Serotonin transporter inhibitor
- SLC6A2 INHIBITOR
- Norepinephrine transporter inhibitor
- ADRA1A ANTAGONIST
- KCNJ10 ANTAGONIST
- SLC6A4 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- KCNH2
- PDE4D
- OPRK1
- PDE3A
- OPRM1
- OPRD1
- NR3C1
- NR1I2
- NPY2R
- NPY1R
- NPSR1
- NPC1
- NFE2L2
- MTOR
- ACHE
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- MPHOSPH8
- PDE5A
- PGR
- PMP22
- VDR
- UGT1A4
- UGT1A3
- TSHR
- TP53
- THPO
- TDP1
- TBXAS1
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACM1
- ACM4
- SCN3A
- SCN2A
- SCN1A
- PLCG1
- NSD2
- MLLT3
- MDR1
- KSYK
- KCNQ1
- KCMB4
- KCMB2
- KCMB1
- KCMA1
- KCJ10
- IL1B
- IFNG
- IDHC
- CP3A7
- CP3A4
- CP2D6
- CP1A2
- ANDR
- ACM5
- SYK
Drug classes
- Adrenergic Agents
- Adrenergic Uptake Inhibitors
- Antidepressive Agents
- Antidepressive Agents, Tricyclic
- Central Nervous System Agents
- Membrane Transport Modulators
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Psychotropic Drugs
- Tricyclic Antidepressant
ATC classes
Cross-references
Synonyms
- AVENTYL
- AVENTYL HYDROCHLORIDE
- NORTRIPTYLINE HYDROCHLORIDE
- PAMELOR
- Pamelor
- nortryptyline
- demethylamitriptylin
- desitriptilina
- desmethylamitriptyline
- noramitriptyline
- nortriptyline hydrochloride
- nortriptyline HCl
- Nortriptilina
- Desitriptilina
- Lumbeck
- Noramitriptyline
- Nortrilen
- Sesaval
- NCI-169453
- NSC-757234
- Allegron
- Aventyl
- Motipress
- Motival
- Acetexa
- Altilev
- Ateben
- Avantyl
- Demethylamitriptylene
- Demethylamitriptyline
- Demethylamitryptyline
- Desitriptyline
- Desmethylamitriptylin
- Desmethylamitriptyline
- Noritren
- Nortriptylinum
- Nortryptiline
- Nortryptyline
Reported adverse events
- Jaundice
- Confusional state
- Dry mouth
- Nausea
- Hypotension
- Brugada syndrome
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