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CLOZAPINE
SynDRA canonical compound SYN0000176 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | HRH4 |
|---|
| Mechanism of action | Serotonin receptor antagonist |
|---|
| Indication | schizophrenia |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- HTR2A
- DRD2
- DRD4
- CHRM1
- HTR1B
- HRH4
- HTR1D
- HRH1
- HTR1E
- HTR2C
- DRD3
- DRD1
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- Serotonin receptor antagonist
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- DRD2 ANTAGONIST
- Dopamine D2 receptor antagonist
- HTR1A FULL AGONIST
- HTR1B FULL AGONIST
- HTR1D FULL AGONIST
- HTR1E FULL AGONIST
- HTR1F FULL AGONIST
- HTR2A INVERSE AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- OPRK1
- OPRD1
- CACNA1C
- ABCB1
- PDE4A
- PDE10A
- OPRM1
- NTSR1
- NR3C1
- NPY2R
- NPY1R
- NFKB1
- MPHOSPH8
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LEPR
- LCK
- KDR
- KDM4A
- IDH1
- HSD17B10
- PDE3A
- PDE4D
- GLS
- PDE5A
- UGT1A8
- UGT1A3
- TSHR
- TRPV1
- TDP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT1A
- KCMB1
- CP3A7
- GCR
- HTR3C
- HTR3D
- HTR3E
- IFNG
- KCMA1
- KCMB2
- CP1A2
- KCMB4
- NPR2
- PPARG
- PRGR
- RGS4
- SMAD2
- SMAD3
- CP2D6
- CACNA1S
- 5HT1B
- 5HT7R
- 5HT1D
- 5HT1E
- 5HT1F
- 5HT2B
- 5HT2C
- 5HT5A
- 5HT6R
- ACM1
- CACNA1F
- ACM4
- ACM5
- ADA1A
- ADA1B
- ADA1D
- ANDR
- CACNA1D
- TLR3
Drug classes
- Atypical Antipsychotic
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- GABA Agents
- GABA Antagonists
- Neurotransmitter Agents
- Psychotropic Drugs
- Serotonin Agents
- Serotonin Antagonists
- Tranquilizing Agents
ATC classes
Cross-references
Synonyms
- CLOZARIL
- Clozaril
- FAZACLO ODT
- VERSACLOZ
- Versacloz
- asaleptin
- azaleptine
- clozapin
- clozaril
- fazaclo
- klozapol
- leponex
- Clozapina
- Clozapine (caraco)
- Clozapine (clozaril)
- Clozapine (fazaclo)
- Clozapine (ivax)
- Clozapine (mylan)
- Clozapine (teva)
- Clozapine (udl)
- Clozapine (versacloz)
- Leponex
- HF-1854
- NSC-757429
- Fazaclo
- Fazaclo odt
- Zaponex
- Clozapine resolution mixture
- Asaleptin
- Clorazil
- Clozapin
- Clozapinum
- Iprox
- Lepotex
- Fazaclo ODT
- C 6305
- HF1854
Reported adverse events
- Cardiomyopathy
- Hypotension
- Seizure
- Syncope
- Myocarditis
- Neutropenia
- Orthostatic hypotension
- Bradycardia
- Seizures
- TIA
- Pericarditis
- ECG
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