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L-745870
SynDRA canonical compound SYN0000172 — structure-anchored drug synonym record
| Clinical phase | Preclinical |
|---|
| Primary target(s) | DRD4 |
|---|
| Mechanism of action | Dopamine receptor antagonist |
|---|
All known targets
- DRD4
- DRD1
- DRD2
- DRD3
- HTR1A
- HTR2A
- HTR6
- HTR7
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- DRD4 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADRA1A
- ADRA2A
- ADRA2B
- ADRA2C
- ADRA1B
- SIGMAR1
- HTR2C
- KCNH2
- NFKB1
- HTR1E
- HTR5A
- KDM4A
- LMNA
- MPHOSPH8
- OPRM1
- OPRD1
- OPRK1
- HTR1B
- PMP22
- POLB
- POLI
- POLK
- TDP1
- TSHR
- HTR1D
- HIF1A
- HRH1
- HDAC6
- ALOX15
- ALOX15B
- ATAD5
- ATXN2
- CHRM2
- CHRM3
- CHRM4
- CHRM5
- CYP1A2
- CYP2C19
- CYP2C9
- CYP2D6
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CACNA1C
- CACNA1D
- CACNA1F
- CACNA1S
- CP1A2
- HTR2B
- MAPT
- UBP1
- UHRF1
Cross-references
Synonyms
- CHEMBL267014
- L-745,870
- L745870
- L 745,870
- UNII-J3OLN3XSX7
- J3OLN3XSX7
- 3-((4-(4-Chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo[2,3-b]pyridine
- 3-(4-[4-Chlorophenyl]piperazin-1-yl)-methyl-1H-pyrrolo[2,3-b]pyridine trihydrochloride
- 3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)-1H-pyrrolo(2,3-b)pyridine
- 3-[[4-(4-chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine
- CPMPP-3
- Tocris-1002
- Lopac-L-131
- Biomol-NT_000049
- AC1NSK75
- Lopac0_000791
- GTPL3303
- BPBio1_001299
- SCHEMBL1059886
- CHEBI:92099
- RefChem:924366
- L745,870
- MFCD00932830
- L 745870 Free Base
- orb1709297
- SCHEMBL29496328
- BDBM85093
- GLXC-10207
- CAS_3853
- IGA98500
- NSC_3853
- BDBM50050463
- PDSP1_001576
- PDSP2_001560
- AKOS040733565
- CCG-204875
- EBC-414071
- SDCCGSBI-0050768.P002
- T11799L
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