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THIOPENTAL
SynDRA canonical compound SYN0000155 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | FAAH |
|---|
| Mechanism of action | GABA receptor antagonist |
|---|
| Indication | anesthetic |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- GABRA1
- GABRG2
- GABRB2
- Gabrb3
- Gabra4
- Gabra5
- Gabra6
- Gabrb1
- Gabrb2
- FAAH
- Gabra3
- Gabre
Mechanisms of action (all sources)
- GABRA1 POSITIVE ALLOSTERIC MODULATOR
- GABRB2 POSITIVE ALLOSTERIC MODULATOR
- GABRG2 POSITIVE ALLOSTERIC MODULATOR
- GABRB3 POSITIVE ALLOSTERIC MODULATOR
- GABRA4 POSITIVE ALLOSTERIC MODULATOR
- GABRG3 POSITIVE ALLOSTERIC MODULATOR
- GABRQ POSITIVE ALLOSTERIC MODULATOR
- GABRA3 POSITIVE ALLOSTERIC MODULATOR
- GABRP POSITIVE ALLOSTERIC MODULATOR
- GABRD POSITIVE ALLOSTERIC MODULATOR
- GABRG1 POSITIVE ALLOSTERIC MODULATOR
- GABRB1 POSITIVE ALLOSTERIC MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- CYP3A4
- HDAC6
- KAT2A
- LMNA
- SLCO1B1
- SLCO1B3
- USP1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Anesthetics
- Anesthetics, Intravenous
- Anticonvulsants
- Central Nervous System Agents
- Central Nervous System Depressants
- GABA Agents
- GABA Modulators
- Hypnotics and Sedatives
- Neurotransmitter Agents
ATC classes
- N01A · ANESTHETICS, GENERAL
- N05C · HYPNOTICS AND SEDATIVES
Cross-references
Synonyms
- PENTOTHAL
- pentothal
- thiopental sodium
- thiomebumal
- thionembutal
- pentothiobarbital
- Thiopental ciii
- Intraval
- Penthiobarbital
- Pentothiobarbital
- Thiomebumal
- Thionembutal
- Thiopentobarbital
- Thiopentobarbitone
- Thiopentone
- Thiothal
- Tiopentale
- Trapanal
- Thiopental [BAN]
- Thiopental solution
- Thiopentobarbituric acid
- Tiopentale [Italian]
- Sodium Pentothal (TN)
- Thiopental (TN)
- Thiopentone sodium (TN)
- Trapanal (TN)
- (+-)-Thiopental
- (+/-)-THIOPENTAL
- (+/-)-Thiopental solution
- JI8Z5M7NA3
- CHEBI:102166
- Intraval sodium
- RefChem:897863
- DTXCID203653
- Thiopental (1mg/ml in Acetonitrile)
- NCGC00159524-01
- EINECS 200-984-3
- UNII-JI8Z5M7NA3
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