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PYRIMETHAMINE
SynDRA canonical compound SYN0000147 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | DHFR | DHFRP1 | HEXA | SLC47A1 | STAT3 |
|---|
| Mechanism of action | dihydrofolate reductase inhibitor |
|---|
| Indication | malaria |
|---|
| Disease area | infectious disease |
|---|
All known targets
- SLC47A1
- DHFR
- HEXA
- CHRM1
- SLC22A1
- dfrA17
- Slc47a2
- Slc47a1
- Slc22a1
- STAT3
- PTR1
- CYP2C9
Mechanisms of action (all sources)
- SLC47A1 INHIBITOR
- dihydrofolate reductase inhibitor
- FOLR1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- KCNH2
- SLC6A3
- HTR2A
- ADRA1A
- ADRA2A
- ESR1
- NR1I2
- PDE3A
- OPRM1
- OPRK1
- OPRD1
- NR3C1
- NPY1R
- NR1H4
- PGR
- NFE2L2
- MLNR
- MC4R
- MC3R
- MAOA
- LMNA
- PDE4D
- ACP1
- PPARD
- SLCO1B1
- TP53
- TDP1
- TBXA2R
- TAAR1
- SMN1
- SMAD3
- SLCO1B3
- SLC6A4
- IDH1
- SLC6A2
- SLC2A1
- SLC29A1
- SAMHD1
- RORC
- PTPN22
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ANDR
- TF65
- SYK
- S47A1
- PRGR
- NSD2
- NFKB1
- NF2L2
- MRGPRX1
- MDM4
- MDM2
- KSYK
- JUN
- JAK2
- IFNG
- IDHC
- HXA9
- HIF1A
- GNRHR
- GLI3
- ESRRA
- EPAS1
- CP2D6
- CP2CJ
- CP1A2
- CP19A
- TR10B
Drug classes
- Dihydrofolate Reductase Inhibitors
- Anti-Infective Agents
- Antimalarials
- Antiparasitic Agents
- Antiprotozoal Agents
- Enzyme Inhibitors
- Folic Acid Antagonists
- Dihydrofolate Reductase Inhibitor Antimalarial
ATC classes
Cross-references
Synonyms
- DARAPRIM
- Daraprim
- FANSIDAR
- chloridin
- chloridine
- diaminopyritamin
- pirimecidan
- pirimetamin
- pyrimethamin
- Pirimetamina
- Chloridine
- Pyrimethaminum
- GNF-PF-5586
- NSC-3061
- RP-4753
- TCMDC-123831
- TCMDC-125860
- WR-2978
- Malacide
- Pyrimethamine component of fansidar
- Chloridin
- Chloridyn
- Darachlor
- Daraclor
- Darapram
- Daraprime
- Daraprin
- Diaminopyritamin
- Erbaprelina
- Ethylpyrimidine
- Khloridin
- Malacid
- Malocid
- Malocide
- Maloprim
- Pirimecidan
- Pirimetamin
Reported adverse events
- Vomiting
- Hypersensitivity
- Pulmonary eosinophilia
- Stevens-Johnson syndrome
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