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HYDROCHLOROTHIAZIDE
SynDRA canonical compound SYN0000142 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SLC12A3 |
|---|
| Mechanism of action | Thiazide diuretic |
|---|
| Indication | congestive heart failure | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
- SLC12A3
- CA1
- CA2
- CA4
- KCNMA1
- CA12
- CA9
- NAPEPLD
- SLC33A1
- ca1
Mechanisms of action (all sources)
- SLC12A3 INHIBITOR
- Thiazide-sensitive sodium-chloride cotransporter inhibitor
- NAPEPLD BINDER
- SLC33A1 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HTR2B
- ABCC2
- MAPK3
- LCK
- LMNA
- MAOA
- MAPK1
- MAPK14
- MC3R
- HTR7
- MC4R
- MC5R
- MLNR
- MMP1
- MMP9
- NPY1R
- KCNH2
- HTR6
- GABBR1
- HTR5A
- HTR3A
- HTR2C
- HTR2A
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- GNAS
- GMNN
- GIPR
- GHSR
- NPY2R
- NR3C1
- NTSR1
- SIGMAR1
- THRB
- TBXAS1
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CA14
- CA5A
- CA5B
- CA6
- CA7
- CP2CJ
Drug classes
- Thiazide Diuretic
- Antihypertensive Agents
- Cardiovascular Agents
- Diuretics
- Membrane Transport Modulators
- Natriuretic Agents
- Sodium Chloride Symporter Inhibitors
ATC classes
- C03A · LOW-CEILING DIURETICS, THIAZIDES
- DIURETICS AND POTASSIUM-SPARING AGENTS IN COMBINATION
- ACE INHIBITORS, COMBINATIONS
- ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
- OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Cross-references
Synonyms
- ACCURETIC
- ALDACTAZIDE
- ALDORIL 15
- ALDORIL 25
- ALDORIL D30
- ALDORIL D50
- AMILORIDE HYDROCHLORIDE AND HYDROCHLOROTHIAZIDE
- AMLODIPINE BESYLATE, VALSARTAN AND HYDROCHLOROTHIAZIDE
- AMTURNIDE
- APRESAZIDE
- APRESOLINE-ESIDRIX
- ATACAND HCT
- hydrochlorothiazid
- hydrochlorthiazide
- hydrochlorzide
- Hidroclorotiazida
- Apresazide
- Carozide
- Chlorosulthiadil
- Copalia-hct
- Dafiro-hct
- Dihydrochlorurite
- Exforge-hct
- Hidrotiazida
- Hydrochlorothiaizide
- Hydrochlorothiazidum
- Hydrochlorthiazide
- Idrotiazide
- Imprida-hct
- Lotensin hct
- Megadiuril
- Newtolide
- Pantemon
- Rasilez-hct
- Servithiazid
- Unipres
- Vetidrex
- NSC-53477
Reported adverse events
- Hyperkalemia
- Hypersensitivity
- Hypotension
- Erythema multiforme
- Stevens-Johnson syndrome
- Pancreatitis
- Angioedema
- Anaphylactic reaction
- Vertigo
- Renal failure
- Cough
- Dizziness
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