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LABETALOL
SynDRA canonical compound SYN0000129 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ADRB2 |
|---|
| Mechanism of action | Adrenergic receptor antagonist |
|---|
| Indication | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
- ADRA1D
- ADRB1
- ADRB2
- ADRA1A
- ADRA2B
- ADRA2C
- ADRB3
- ADRA1B
- Htr1a
- STE24
- SLC6A3
- SLC6A2
Mechanisms of action (all sources)
- Adrenergic receptor antagonist
- ADRA1A ANTAGONIST
- ADRA2A ANTAGONIST
- ADRB1 ANTAGONIST
- ADRB2 ANTAGONIST
- ADRA2C ANTAGONIST
- ADRA1D ANTAGONIST
- ADRA1B ANTAGONIST
- ADRA2B ANTAGONIST
- ADRB3 ANTAGONIST
- TADA2A ANTAGONIST
- ADRB2 PARTIAL AGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- OPRM1
- NPY2R
- NPY1R
- KCNH2
- DRD2
- DRD3
- MAPK3
- OPRD1
- NR3C1
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MAPK14
- HRH2
- MAPK1
- MAOB
- MAOA
- LMNA
- LCK
- KDR
- KDM4E
- HTR6
- HTR2C
- HTR2A
- HSD17B10
- OPRK1
- ABCB1
- PDE3A
- SLC6A4
- UGT1A9
- UGT1A1
- TTR
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
- SMN1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- CP2CJ
- CP2D6
- GLI3
- MDR1
- NR1I2
- NTM1A
Drug classes
- Adrenergic beta-Antagonists
- beta-Adrenergic Blocker
- Adrenergic Agents
- Adrenergic alpha-1 Receptor Antagonists
- Adrenergic alpha-Antagonists
- Adrenergic Antagonists
- Antihypertensive Agents
- Cardiovascular Agents
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Sympathomimetics
ATC classes
- C07A · BETA BLOCKING AGENTS
- BETA BLOCKING AGENTS AND THIAZIDES
- BETA BLOCKING AGENTS AND OTHER DIURETICS
Cross-references
Synonyms
- LABETALOL HYDROCHLORIDE
- LABETALOL HYDROCHLORIDE IN DEXTROSE
- LABETALOL HYDROCHLORIDE IN SODIUM CHLORIDE
- NORMODYNE
- NORMOZIDE
- TRANDATE
- TRANDATE HCT
- Trandate
- labetalol hydrochloride
- albetol
- ibidomide
- labetalol HCl
- SCH-19927
- Ibidomide
- Normozide
- AH-5158A FREE BASE
- SCH-15719W FREE BASE
- Albetol
- Labetalolum
- Labetolol
- AH-5158
- Labetalol (INN)
- Labetalol [INN:BAN]
- Labetalolum [INN-Latin]
- Normodyne (TN)
- Sch-19927
- Trandate (TN)
- R5H8897N95
- CHEBI:6343
- CHEBI:167638
- labetalolo
- ApoLabetalol
- Apo Labetalol
- RefChem:58510
- DTXCID603191
- C07AG01
- AH5158
- MFCD00242941
Reported adverse events
- Hypersensitivity
- Hypotension
- Dizziness
- Hepatic necrosis
- Nausea
- Dyspepsia
- Fatigue
- Vomiting
- Bradycardia
- Headache
- Vertigo
- Rash
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