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TRIFLUOPERAZINE
SynDRA canonical compound SYN0000099 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | DRD2 |
|---|
| Mechanism of action | Dopamine receptor antagonist |
|---|
| Indication | schizophrenia |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- DRD2
- HTR2C
- HTR2A
- DRD4
- HRH1
- DRD3
- ADRA1A
- CALM
- CALM1
- Lyz1
- HTR7
- Htr1a
Mechanisms of action (all sources)
- Dopamine receptor antagonist
- HTR2A ANTAGONIST
- Serotonin 2a (5-HT2a) receptor antagonist
- HTR2C ANTAGONIST
- Serotonin 2c (5-HT2c) receptor antagonist
- DRD2 ANTAGONIST
- D2-like dopamine receptor antagonist
- DRD3 ANTAGONIST
- DRD4 ANTAGONIST
- HRH1 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB11
- MC4R
- OPRK1
- CHRM1
- DHCR24
- DRD1
- SC5D
- SLC6A2
- ESR1
- MLNR
- SLC6A4
- HRH2
- MAPT
- NOX1
- PDE3A
- OPRM1
- KDM4A
- OPRD1
- NTSR1
- NR3C1
- NPY2R
- KDM4E
- LCK
- NPY1R
- NPSR1
- NPC1
- NFKB1
- MBNL1
- LMNA
- NFE2L2
- MAOA
- MTOR
- PDE5A
- MAPK1
- MPHOSPH8
- MMP9
- MMP1
- MAPK14
- MC5R
- MAPK3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACM1
- PE2R2
- M4K2
- MDR1
- MK01
- MLLT3
- NNMT
- NR1I2
- NSD2
- NTM1A
- PAFA
- PNMT
- KCNQ1
- RARA
- ROS1
- RPGF4
- RXFP1
- SMAD2
- STK33
- SYK
- TPO
- UBP1
- KSYK
- KCMB2
- ACM4
- ESRRA
- ANDR
- APAF
- COMT
- CP19A
- CP1A2
- CP2CJ
- CP2D6
- CP3A4
- CP3A7
- GAMT
- KCMB1
- GEMI
- GLI3
- GNMT
Drug classes
- Antiemetics
- Antipsychotic Agents
- Central Nervous System Agents
- Central Nervous System Depressants
- Dopamine Agents
- Dopamine Antagonists
- Gastrointestinal Agents
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Psychotropic Drugs
- Tranquilizing Agents
- Phenothiazine
ATC classes
Cross-references
Synonyms
- STELAZINE
- TRIFLUOPERAZINE HYDROCHLORIDE
- trifluoperazin
- trifluoromethylperazine
- trifluoroperazine
- trifluperazine
- triflurin
- triperazine
- trifluoperazine hydrochloride
- trifluoperazine dihydrochloride
- trifluoperazine HCl
- flupazine
- Trifluoperazina
- Apo-trifluoperazine
- Flurazine
- NSC-17474
- NSC-46061
- RP-7623
- Amylozine
- Stelazine
- Stelazine fte
- Calmazine
- Eskazine
- Fluoperazine
- Modalina
- Stellazine
- TFP
- Trifluoperazin
- Trifluoperazinum
- Trifluoromethylperazine
- Trifluoroperazine
- Trifluperazine
- Triflurin
- Trifluroperizine
- Triftazin
- Triftazine
- Triperazine
- Triphtazin
Reported adverse events
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