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DILTIAZEM
SynDRA canonical compound SYN0000094 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CACNA1C |
|---|
| Mechanism of action | Calcium channel blocker |
|---|
| Indication | angina pectoris | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
- CACNA1C
- CACNA1S
- HTR3A
- CACNA1D
- CACNA1F
- CACNA2D1
- CACNG1
- ABCB1
- SCN3A
- SCN2A
- SCN1A
- Kcnc1
Mechanisms of action (all sources)
- Calcium channel blocker
- CACNA1C BLOCKER
- Voltage-gated L-type calcium channel blocker
- CACNA1S BLOCKER
- CACNA1D BLOCKER
- CACNA1F BLOCKER
- CACNA2D1 BLOCKER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- SCN5A
- ADRA1A
- ABCB11
- NEIL1
- MC4R
- MC5R
- MLNR
- MMP1
- MMP9
- MPHOSPH8
- NFE2L2
- MBD4
- NPY1R
- NPY2R
- NR3C1
- NTHL1
- NTSR1
- OPRD1
- MC3R
- MAPK3
- OPRM1
- HTR6
- HRH1
- HRH2
- HRH3
- HTR1A
- HTR2B
- HTR2C
- HTT
- MAPK14
- KAT2A
- KMT2A
- LCK
- LMNA
- MAOA
- MAPK1
- OPRK1
- PDE3A
- HDAC6
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP3A4
- CP3A7
- ESRRA
- KSYK
- MDR1
- S12A5
- SCN10A
- SCN11A
- SCN4A
- SCN7A
- SCN8A
- SCN9A
- SYK
Drug classes
- Calcium Channel Antagonists
- Calcium Channel Blocker
- Antihypertensive Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Membrane Transport Modulators
- Vasodilator Agents
- Cytochrome P450 3A4 Inhibitors
ATC classes
- C05A · AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
- C08D · SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS
Cross-references
Synonyms
- CARDIZEM
- CARDIZEM CD
- CARDIZEM LA
- CARDIZEM SR
- CARTIA XT
- Cardizem
- Cartia
- DILACOR XR
- DILT-CD
- DILTIAZEM HYDROCHLORIDE
- DILTIAZEM HYDROCHLORIDE IN 0.72% SODIUM CHLORIDE
- DILTIAZEM HYDROCHLORIDE IN DEXTROSE 5%
- (+)-Diltiazem
- dilzem
- d-Diltiazem
- d-cis-Diltiazem
- diltiazem hydrochloride
- diltiazem malate
- diltiazem HCl
- Diltiazem extended release
- Ditiaz
- Surazem
- Acalix
- Adizem
- Aldizem
- Anoheal
- Cardil
- Citizem
- Dilacor
- Dilcontin
- Dilren
- Diltia
- Diltiazemum
- Dilticard
- Dilzen
- Endrydil
- Viazem
- Cardizen LA
Reported adverse events
- Abnormal dreams
- Amblyopia
- Petechiae
- Stevens-Johnson syndrome
- Dizziness
- Hypotension
- Pruritus
- Alopecia
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