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VERAPAMIL
SynDRA canonical compound SYN0000089 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CACNA1G |
|---|
| Mechanism of action | Calcium channel blocker |
|---|
| Indication | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
- CACNA1S
- CACNA1C
- CACNA1D
- KCNA7
- SLC29A4
- CYP3A4
- KCNA10
- CACNA1G
- CACNA1F
- TPCN1
- NALCN
- TPCN2
Mechanisms of action (all sources)
- Calcium channel blocker
- CACNA1C BLOCKER
- Voltage-gated L-type calcium channel blocker
- CACNA1S BLOCKER
- CACNA1D BLOCKER
- CACNA1F BLOCKER
- CYP3A4 INHIBITOR
- KCNA7 MODULATOR
- KCNA10 MODULATOR
- NALCN MODULATOR
- SLC29A4 INHIBITOR
- TPCN1 INHIBITOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ESR1
- PDE4D
- NR1I2
- ADRA2C
- ADRA2B
- PDE5A
- PDE4A
- PDE3A
- OPRM1
- OPRK1
- NPY1R
- PGR
- OPRD1
- NTSR1
- NR3C1
- NR1I3
- PMP22
- NR1H4
- NR1H3
- NR1H2
- NPY2R
- ABCB11
- PPARD
- NPSR1
- LCK
- LMNA
- MAOA
- MAPK1
- MAPK14
- MAPK3
- MC3R
- MC4R
- MC5R
- MLNR
- MMP1
- MMP9
- MPHOSPH8
- MTOR
- NFE2L2
- PPARA
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ANDR
- CP2D6
- CP3A4
- CP3A7
- ESRRA
- GLI3
- JUN
- KCA10
- MDR1
- PRGR
- S29A4
Drug classes
- Calcium Channel Antagonists
- Calcium Channel Blocker
- Cytochrome P450 3A4 Inhibitors
- P-Glycoprotein Inhibitors
- Cytochrome P450 3A Inhibitors
- Anti-Arrhythmia Agents
- Calcium Channel Blockers
- Calcium-Regulating Hormones and Agents
- Cardiovascular Agents
- Membrane Transport Modulators
- Vasodilator Agents
ATC classes
- C08D · SELECTIVE CALCIUM CHANNEL BLOCKERS WITH DIRECT CARDIAC EFFECTS
- ACE INHIBITORS, COMBINATIONS
Cross-references
Synonyms
- CALAN
- CALAN SR
- COVERA-HS
- Calan
- ISOPTIN
- Isoptin
- TARKA
- TRANDOLAPRIL AND VERAPAMIL HYDROCHLORIDE
- VERAPAMIL HYDROCHLORIDE
- VERELAN
- VERELAN PM
- Verelan
- RS-Verapamil
- (+/-)-Verapamil
- verapamil hydrochloride
- verapamil HCl
- Verapamilo
- Iproveratril
- Verapamil slow release
- CP-16,533-1
- CP-165331
- D-365
- NSC-272306NA
- Arpamyl
- Calcan
- Cordilox
- Dexverapamil
- Dilacoran
- Drosteakard
- Isoptimo
- Isotopin
- Vasolan
- Veracim
- Verapamilum
- Veraptin
- Verexamil
- Bosoptin (TN)
- Calan (TN)
Reported adverse events
- Constipation
- Flushing
- Headache
- Nausea
- Bradycardia
- Dizziness
- Fatigue
- Hypotension
- Stevens-Johnson syndrome
- Rash
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