← SynDRA

MAFENIDE

SynDRA canonical compound SYN0000085 — structure-anchored drug synonym record

All known targets

• CA6
• CA12
• CA14
• CA2
• CA4
• CA9
• Ca15
• mtcA1
• folP
• cynT
• ca1
• NCE103

Mechanisms of action (all sources)

• Carbonic anhydrase inhibitor
• CA2 INHIBITOR
• CA12 INHIBITOR
• CA6 INHIBITOR
• CA14 INHIBITOR
• CA4 INHIBITOR
• folP INHIBITOR

Bioactivity evidence (ChEMBL activities table — not curator-asserted)

• ACHE
• SAMHD1
• KDR
• MAOA
• MAPT
• OPRM1
• PDE3A
• PDE4A
• PGR
• PTGS1
• SLC6A2
• ADORA3
• SLC6A3
• SLC6A4
• SLCO1B1
• SLCO1B3
• SMN1
• SOS1
• SOS2
• TBXA2R
• KDM4E
• KCNH2
• HTR2B
• HTR1A
• ADRA1A
• ADRA2A
• AR
• CBX1
• CHRM1
• CHRM2
• CYP1A2
• CYP2C19
• CYP2C9
• CYP2D6
• CYP3A4
• DRD1
• ESR1
• F2
• GMNN
• HDAC6

Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)

• ANDR
• KCMB2
• MDR1

Drug classes

• Methylated Sulfonamide Antibacterial
• Anti-Bacterial Agents
• Anti-Infective Agents
• Anti-Infective Agents, Local
• Carbonic Anhydrase Inhibitors
• Enzyme Inhibitors

ATC classes

• D06B · CHEMOTHERAPEUTICS FOR TOPICAL USE

Cross-references

• PubChem CID: 3998
• ChEMBL: CHEMBL419
• DrugBank: DB06795
• ChEBI: CHEBI:6633
• KEGG: D01166
• RxNorm: 6572
• PDB: 6LH
• Wikipedia: Mafenide
• TTD: D0K1QD
• LINCS BRD: BRD-K30649484

Synonyms

• MAFENIDE ACETATE
• SULFAMYLON
• Sulfamylon
• 4-(Aminosulfonyl)benzylamine
• 4-Homosulfanilamide
• 4-Sulfamoylbenzylamine
• ambamide
• benzamsulfonamide
• homosulfanilamide
• malfamin
• maphenid
• maphenide
• p-Sulfamoylbenzylamine
• mafenide acetate
• m,afenide hydrochloride
• m,afenide HCl
• Mafenida
• 4-homosulfanilamide
• D06BA03
• NSC-34632
• 4-(Aminomethyl)benzenesulfonamide
• 4-Aminomethylbenzenesulfonamide
• Ambamide
• Emilene
• Maphenide
• Maphenid
• Malfamin
• Homosul
• Homonal
• Benzamsulfonamide
• Homosulfanilamide
• Marprontil
• Mesudrin
• Septicid
• Neofamid
• Mesudin
• Paramenyl
• Benzenesulfonamide, 4-(aminomethyl)-

Reported adverse events

• Acidosis
• Rash