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METHOXSALEN
SynDRA canonical compound SYN0000077 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CYP3A4 |
|---|
| Mechanism of action | DNA synthesis inhibitor |
|---|
| Indication | psoriasis |
|---|
| Disease area | dermatology |
|---|
All known targets
- CYP1A2
- CYP2A6
- ACHE
- CYP1A1
- CYP2A13
- CYP3A4
- TAS2R20
- MAOA
- PPO2
Mechanisms of action (all sources)
- DNA synthesis inhibitor
- TAS2R20 AGONIST
- CYP2A6 BINDER
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PDE4A
- ESR1
- MC3R
- OPRM1
- OPRK1
- OPRD1
- NR3C1
- NPY2R
- NPY1R
- NFE2L2
- MMP9
- MMP1
- MC5R
- MC4R
- MAPK3
- HRH2
- MAPK14
- MAPK1
- LCK
- KDR
- KCNH2
- KCNA1
- HTR6
- HTR2C
- HTR2B
- HTR2A
- HTR1A
- PDE3A
- ADORA1
- PDE5A
- SLC6A3
- VDR
- TSHR
- TBXAS1
- TBXA2R
- TARDBP
- TACR2
- TACR1
- SLCO2B1
- SLCO1B3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- AHR
- ANDR
- CP1A2
- CP2C9
- CP2CJ
- CP2D6
- CP3A4
- CP3A7
- GLI3
- MDR1
- NR1I2
Drug classes
- Photoabsorption
- Cross-Linking Reagents
- Dermatologic Agents
- Indicators and Reagents
- Photosensitizing Agents
- Radiation-Sensitizing Agents
- Psoralen
- Photoactivated Radical Generator
ATC classes
- D05B · ANTIPSORIATICS FOR SYSTEMIC USE
- D05A · ANTIPSORIATICS FOR TOPICAL USE
Cross-references
Synonyms
- 8-MOP
- OXSORALEN
- OXSORALEN-ULTRA
- UVADEX
- Uvadex
- methoxsalene
- 8-Methoxypsoralen
- 8-Methoxypsoralene
- deltapsoralen
- meladinin
- meladinine
- meladoxen
- meloxine
- oxsoralen
- xanthotoxin
- xanthotoxine
- 8-methoxsalen
- Metoxalen
- Oxypsoralen
- Puvalen
- Vitpso
- METHOXSALEN COMPONENT OF SM-88
- NSC-45923
- 8-mop
- Deltasoralen
- Meladinine
- Oxsoralen
- Oxsoralen-ultra
- Puvasoralen-8
- Ammodin
- Ammoidin
- Dermox
- Geroxalen
- Meladinin
- Meladinina
- Meladoxen
- Meloxine
Reported adverse events
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