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CLOMIPRAMINE
SynDRA canonical compound SYN0000074 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | SLC6A4 |
|---|
| Mechanism of action | SERT inhibitor |
|---|
| Indication | obsessive compulsive disorder (OCD) |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- SLC6A4
- SLC6A2
- SLC6A3
- ADRA1A
- GSTP1
- HTR2C
- HTR2A
- HTR2B
- Adra2a
- Htr6
- Htr1f
- Htr2a
Mechanisms of action (all sources)
- SERT inhibitor
- SLC6A4 INHIBITOR
- Serotonin transporter inhibitor
- ADRA1A ANTAGONIST
- SLC6A3 INHIBITOR
- SLC6A2 INHIBITOR
- serotonin transporter (SERT) inhibitor
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- HRH3
- OPRM1
- KCNH2
- OPRK1
- ADRB1
- MC5R
- OPRD1
- NR3C1
- NPY2R
- NPY1R
- NPSR1
- MTOR
- MMP9
- MMP1
- MLNR
- MC3R
- MC4R
- PDE4A
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LMNA
- LCK
- KDR
- KDM4E
- IDH1
- PDE3A
- ABCB1
- HMGCR
- PDE5A
- USP1
- TSHR
- TP53
- THRB
- THPO
- TDP1
- TBXAS1
- TBXA2R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ACM1
- SMAD3
- SMAD2
- SCN3A
- SCN2A
- SCN1A
- SC6A3
- SC6A2
- ROS1
- RARA
- PRGR
- PPARG
- PPARD
- NSD2
- NR1H4
- NPR2
- KSYK
- JUN
- IFNG
- GLI3
- CP3A7
- CP3A4
- CP2D6
- CP2CJ
- CP1A2
- CASP7
- CASP3
- ANDR
- SYK
Drug classes
- Antidepressive Agents
- Antidepressive Agents, Tricyclic
- Central Nervous System Agents
- Membrane Transport Modulators
- Neurotransmitter Agents
- Neurotransmitter Uptake Inhibitors
- Psychotropic Drugs
- Selective Serotonin Reuptake Inhibitors
- Serotonin Agents
- Tricyclic Antidepressant
ATC classes
Cross-references
Synonyms
- ANAFRANIL
- Anafranil
- CLOMIPRAMINE HYDROCHLORIDE
- Calmera
- Caniquell
- Clomicalm
- chlorimipramine
- clomipramine hydrochloride
- clomipramine HCl
- Clomipramina
- 3-chloro-iminodibenzyl
- Anapramine
- Chlorimipramine
- NSC-169865
- Chlomipramine
- Clomipraminum
- Hydiphen
- Monochlorimipramine
- Anafranil base
- G 34586
- Anafranil (TN)
- Anafranil (free base)
- Clomipramina [INN-Spanish]
- Clomipramine (INN)
- Clomipramine [INN:BAN]
- Clomipraminum [INN-Latin]
- 3-Chloroimipramine
- NSC 169865
- clomipramine (ema epar veterinary)
- NUV44L116D
- 3-Chloro-Iminodibenzyl
- DTXCID602844
- CHEBI:47780
- RefChem:58431
- Monohydrochloride, Clomipramine
- N06AA04
- NCGC00015264-08
- CLOMIPRAMINE [INN]
Reported adverse events
- Suicide
- Headache
- Nausea
- Rash
- Tachycardia
- Vomiting
- Agitation
- Anxiety
- Constipation
- Cough
- Dysuria
- Increased appetite
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