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MECAMYLAMINE
SynDRA canonical compound SYN0000063 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CHRNA2 |
|---|
| Mechanism of action | Acetylcholine receptor antagonist |
|---|
| Indication | hypertension |
|---|
| Disease area | cardiology |
|---|
All known targets
- CHRNA3
- CHRNA2
- CHRNB4
- CHRNA1
- CHRNA4
- CHRNA6
- CHRNA7
- CHRNB2
- CHRNB3
Mechanisms of action (all sources)
- Acetylcholine receptor antagonist
- CHRNB4 NEGATIVE ALLOSTERIC MODULATOR
- Neuronal acetylcholine receptor; alpha3/beta4 negative allosteric modulator
- CHRNA3 NEGATIVE ALLOSTERIC MODULATOR
- CHRNA1 MODULATOR
- CHRNA2 MODULATOR
- CHRNA3 MODULATOR
- CHRNA4 MODULATOR
- CHRNA6 MODULATOR
- CHRNA7 MODULATOR
- nicotinic receptor antagonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ADORA1
- NPY1R
- OPRM1
- OPRK1
- OPRD1
- OGG1
- NTHL1
- NR3C1
- NR1I2
- NFKB1
- MAOA
- NEIL2
- NEIL1
- MUTYH
- MPG
- MLNR
- MC4R
- MC3R
- PDE3A
- PDE4D
- PGR
- PKM
- THPO
- TDG
- TBXA2R
- SMUG1
- SMPD1
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
- SLC29A1
- SAMHD1
- RGS4
- PTGS2
- POLI
- MBD4
- LMNA
- ADORA2A
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACHA
- ACHA2
- ACHA4
- ACHA6
- ACHA7
Drug classes
- Antihypertensive Agents
- Cardiovascular Agents
- Cholinergic Agents
- Cholinergic Antagonists
- Ganglionic Blockers
- Neurotransmitter Agents
- Nicotinic Antagonists
- Peripheral Nervous System Agents
- Autonomic Ganglionic Blocker
ATC classes
- C02B · ANTIADRENERGIC AGENTS, GANGLION-BLOCKING
Cross-references
Synonyms
- INVERSINE
- MECAMYLAMINE HYDROCHLORIDE
- Vecamyl
- mecamine
- revertina
- mecamylamine hydrochloride
- mecamylamine HCl
- Mecamilamina
- Mecamine
- Mecamylaminum
- Mekamine
- Mevasine
- Revertina
- Versamine
- Inversine hydrochloride
- Mecamilamina [DCIT]
- Mecamilamina [Italian]
- Mevasin hydrochloride
- Inversine (TN)
- Mecamylamine [INN:BAN]
- Mecamylaminum [INN-Latin]
- N-Methyl-2-isocamphanamine
- N,2,3,3-Tetramethyl-2-norbornamine
- N,2,3,3-Tetramethyl-2-norcamphanamine
- N,2,2,3-tetramethylbicyclo[2.2.1]heptan-3-amine
- N,2,3,3-Tetramethylbicyclo[2.2.1]heptan-2-amine
- 2-Methylamino-2,3,3-trimethylnorbornane
- 2-Methylaminoisocamphane
- 3-Methylaminoisocamphane
- 3-Methylaminoisokamfan
- 3-Methylaminoisokamfan [Czech]
- 3-beta-Methylamino-2,2,3-trimethylbicyclo(2.2.1)heptane
- N,2,3,3-Tetramethyl-2-norbornanamine
- Bicyclo(2.2.1)heptan-2-amine, N,2,3,3-tetramethyl-
- 6EE945D3OK
- DTXCID903240
- Bicyclo[2.2.1]heptan-2-amine, N,2,3,3-tetramethyl-
- N,2,3,3-tetramethylbicyclo(2.2.1)heptan-2-amine
Reported adverse events
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