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FENRETINIDE
SynDRA canonical compound SYN0000060 — structure-anchored drug synonym record
| Clinical phase | Phase 3 |
|---|
| Primary target(s) | CYP2C8 | CYP3A5 | RARA | RARG |
|---|
| Mechanism of action | apoptosis stimulant | retinoid receptor agonist |
|---|
All known targets
Mechanisms of action (all sources)
- apoptosis stimulant
- retinoid receptor agonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- RBP4
- DEGS1
- PSAP
- RAPGEF3
- MMP2
- MMP9
- MPHOSPH8
- MTOR
- NFE2L2
- NFKB1
- NR1H4
- NR3C1
- PMP22
- PPARD
- PPARG
- RAB9A
- ALDH1A1
- MAPK1
- RGS4
- RORC
- RXRA
- RXRB
- RXRG
- SMAD3
- SMN1
- SMPD1
- TDP1
- THPO
- THRB
- TP53
- USP1
- MAPT
- LMNA
- ALOX15
- ESR1
- APEX1
- ASAH1
- ATAD5
- ATXN2
- BLM
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACES
- ANDR
- HDAC9
- IDHC
- IL1B
- KSYK
- MDM2
- MDM4
- NF2L2
- NR1I2
- NSD2
- PAFA
- PRGR
- SMAD2
- SYK
- TPO
- TR10B
- GPR32
- GLSK
- GLI3
- CP2CJ
- BAP1
- CASP3
- CASP7
- CP19A
- CP1A2
- CP2C9
- CP2D6
- ESRRA
- CP3A4
- CP3A7
- CREB1
- DRD2
- DRD3
- ESR2
- TSHR
Drug classes
- Anticarcinogenic Agents
- Antineoplastic Agents
Cross-references
Synonyms
- Fenretinida
- 4-hpr
- All-trans-4'-hydroxyretinanilide
- N-(4-hydroxyphenyl)retinamide
- Retinamide, n-(4-hydroxyphenyl)-
- Rii retinamide
- MCN-R-1967
- NSC-760419
- RT-101
- ST-602
- SYT-101
- Fenretinide (pulmonary Pseudomonas aeruginosa infections in cystic fibrosis), McGill University
- LXS/4-HPR
- Fenretinide (Ewing's sarcoma), Cancer Research UK
- Fenretinide (ILE formulation), Children's Hospital LA
- Fenretinide (intralipid emulsion formulation), Children's Hospital of Los Angeles
- Fenretinide (intravenous, cancer), SciTech Development
- Fenretinide (iv), Children's Hospital LA
- Fenretinide (oral, AMD), Sytera
- Fenretinide (soft gel capsule, AMD), ReVision Therapeutics
- Fenretinide (soft gel capsule, AMD), Sirion
- Fenretinide (topical, actinic keratosis and cancer), SciTech Development
- Fenretinide (intravenous emulsion, lymphoma/solid tumors/pediatric neuroblastomas/pediatric leukemia), CerRx
- Fenretinide (oral powder/Lym-X-Sorb, neuroblastoma), BioMolecular Products
- 4-HPR
- N-(4-Hydroxyphenyl)retinamide
- 4-hydroxyphenylretinamide
- 4-Hydroxyphenyl retinamide
- Retinoic acid p-hydroxyanilide
- all-trans-4'-Hydroxyretinanilide
- McN-R-1967
- Fenretinidum
- 4-hydroxy(phenyl)retinamide
- N-(4-Hydroxyphenyl)all-Trans Retinamide
- Retinamide, N-(4-hydroxyphenyl)-
- Retinoic acid p-hydroxyphenylamide
- 4-(hydroxyphenyl)retinamide
- 15-[(4-hydroxyphenyl)amino]retinal
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