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METOPROLOL
SynDRA canonical compound SYN0000055 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | ADRB2 |
|---|
| Mechanism of action | Adrenergic receptor antagonist |
|---|
| Indication | angina pectoris | hypertension | myocardial infarction |
|---|
| Disease area | cardiology |
|---|
All known targets
- ADRB1
- ADRB2
- Adrb1
- Adrb2
- Adrb3
- Htr1a
Mechanisms of action (all sources)
- Adrenergic receptor antagonist
- ADRB1 ANTAGONIST
- Beta-1 adrenergic receptor antagonist
- ADRB2 ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PDE4D
- NPY2R
- NPY1R
- CYP2J2
- DRD2
- ABCB1
- MAPK14
- NR3C1
- NPSR1
- MMP9
- MMP1
- MLNR
- MC5R
- MC4R
- MC3R
- MAPK3
- MAPK1
- OPRD1
- MAOA
- LCK
- KCNH2
- KAT2A
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HRH3
- HRH2
- HRH1
- HMGCR
- NTSR1
- OPRK1
- GMNN
- SLC22A1
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ACM1
- ANDR
- CP2D6
- GCR
- MDR1
- PTBP1
Drug classes
- Adrenergic beta-Antagonists
- beta-Adrenergic Blocker
- Adrenergic Agents
- Adrenergic Antagonists
- Adrenergic beta-1 Receptor Antagonists
- Anti-Arrhythmia Agents
- Antihypertensive Agents
- Cardiovascular Agents
- Neurotransmitter Agents
- Peripheral Nervous System Agents
- Sympatholytics
ATC classes
- C07A · BETA BLOCKING AGENTS
- BETA BLOCKING AGENTS AND THIAZIDES
- BETA BLOCKING AGENTS AND OTHER DIURETICS
- BETA BLOCKING AGENTS, OTHER COMBINATIONS
Cross-references
Synonyms
- DUTOPROL
- KAPSPARGO SPRINKLE
- Kapspargo
- LOPRESSIDONE
- LOPRESSOR
- LOPRESSOR HCT
- Lopressor
- Lopressor HCT
- METOPROLOL SUCCINATE
- METOPROLOL TARTRATE
- METOPROLOL TARTRATE AND HYDROCHLOROTHIAZIDE
- TOPROL-XL
- metoprolol fumarate
- metoprolol succinate
- beatrolol
- metoprolol tartrate
- (rs)-metoprolol
- Beatrolol
- Dl-metoprolol
- Lopressidone
- Metoprolol slow release
- Seroken
- CGP-2175
- H-93/26
- BelocDuriles
- Betaloc
- BetalocAstra
- Betalok
- Dutoprol
- Lopresor
- Lopresoretic
- Meijoprolol
- Metohexal
- Metoprololum
- Metroprolol
- Preblok
- Presolol
- Seloken
Reported adverse events
- Hypoglycemia
- Diabetes
- Nausea
- Vomiting
- Agranulocytosis
- Depression
- Rhinitis
- Gangrene
- Headache
- Pruritus
- Wheezing
- Bradycardia
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