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DIAZEPAM
SynDRA canonical compound SYN0000051 — structure-anchored drug synonym record
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | GABRQ |
|---|
| Mechanism of action | Benzodiazepine receptor agonist |
|---|
All known targets
- GABRA1
- GABRA2
- GABRA3
- GABRB1
- GABRB2
- GABRG3
- GABRG2
- GABRA4
- GABRA5
- GABRB3
- GABRQ
- GABRG1
Mechanisms of action (all sources)
- Benzodiazepine receptor agonist
- GABRA1 POSITIVE ALLOSTERIC MODULATOR
- GABRB2 POSITIVE ALLOSTERIC MODULATOR
- GABRG2 POSITIVE ALLOSTERIC MODULATOR
- GABRB3 POSITIVE ALLOSTERIC MODULATOR
- GABRA4 POSITIVE ALLOSTERIC MODULATOR
- GABRG3 POSITIVE ALLOSTERIC MODULATOR
- GABRQ POSITIVE ALLOSTERIC MODULATOR
- GABRA3 POSITIVE ALLOSTERIC MODULATOR
- GABRP POSITIVE ALLOSTERIC MODULATOR
- GABRD POSITIVE ALLOSTERIC MODULATOR
- GABRG1 POSITIVE ALLOSTERIC MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- OPRK1
- ORM1
- ESR1
- ALB
- ABCB1
- MC4R
- MAPK1
- MAPK14
- MAPK3
- MC3R
- MLNR
- MC5R
- LCK
- MMP1
- MMP9
- NPY1R
- MAOA
- KCNH2
- NR3C1
- HTR6
- HTR3A
- HTR2C
- HTR2B
- HTR2A
- HTR1D
- HTR1A
- HRH3
- HRH2
- HRH1
- HMGCR
- HDAC6
- NPY2R
- OPRD1
- NTSR1
- GLP1R
- TDP1
- TBXAS1
- TBXA2R
- TACR2
- TACR1
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- ADA1A
- ANDR
- ATAD5
- CP2C9
- CP2CJ
- GCR
- GLI3
- NR1I2
- PRGR
Drug classes
- Adjuvants, Anesthesia
- Anesthetics
- Anesthetics, Intravenous
- Anti-Anxiety Agents
- Anticonvulsants
- Antiemetics
- Central Nervous System Agents
- Central Nervous System Depressants
- GABA Agents
- GABA Modulators
- Gastrointestinal Agents
- Hypnotics and Sedatives
ATC classes
Cross-references
Synonyms
- DIASTAT
- DIASTAT ACUDIAL
- DIAZEPAM INTENSOL
- DIZAC
- Diastat
- Libervant
- Q-PAM
- VALIUM
- VALRELEASE
- VALTOCO
- Valium
- RO-5-2807
- valium
- Ansiolisina
- Centrazepam
- Diacepin
- NRL-1
- Servizepam
- Tranquase
- LA-III
- NSC-169897
- NSC-77518
- RO-52807
- WY-3467
- Alupram 10
- Alupram 2
- Alupram 5
- Apozepam
- Atensine
- Dialar
- Dialar fte
- Diastat acudial
- Diazepam intensol
- Dizac
- E-pam
- Paxel
- Q-pam
Reported adverse events
- Injury
- Dependence
- Incontinence
- Headache
- Rash
- Bradycardia
- Anterograde amnesia
- Hypotension
- Asthenia
- Ataxia
- Hiccups
- Somnolence
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