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TROGLITAZONE
SynDRA canonical compound SYN0000046 — structure-anchored drug synonym record
| Clinical phase | Withdrawn |
|---|
| Approval status | Approved · OTC |
|---|
| Primary target(s) | PPARG |
|---|
| Mechanism of action | PPAR receptor agonist |
|---|
All known targets
- PPARG
- AKR1B1
- TRPM3
- CYP3A4
- ABCB11
- Ido1
- TBXAS1
- PTPN1
- Maob
- Maoa
- MAPK1
- MAOB
Mechanisms of action (all sources)
- Insulin sensitizer
- PPAR receptor agonist
- PPARG AGONIST
- Peroxisome proliferator-activated receptor gamma agonist
- PPARG FULL AGONIST
- TRPM3 MODULATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- PPARA
- PTGS1
- ESR1
- NR1H4
- RARA
- CHRM1
- NR1I2
- PTGS2
- NR1I3
- AR
- DRD3
- NR3C1
- DRD1
- PGR
- PDE4D
- PDE4A
- SLC6A2
- ESR2
- SLC6A3
- ADRA1A
- HTR2A
- HTR1A
- PDE3A
- MLNR
- LCK
- KCNH2
- MMP9
- OPRD1
- NFE2L2
- NTSR1
- KDM1A
- OPRK1
- KDR
- MAPK14
- NPY1R
- MAPK3
- MMP1
- MC3R
- MC4R
- MC5R
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- 5HT2A
- ANDR
- RXFP1
- RPGF3
- RAPGEF3
- PRGR
- NF2L2
- HSPB1
- GLI3
- GABRG2
- GABRB2
- GABRA2
- GABRA1
- ESRRA
- CP3A7
- CP3A4
- CP2CJ
- CP2C9
- CP19A
- TSHR
Drug classes
ATC classes
- A10B · BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
Cross-references
Synonyms
- PRELAY
- REZULIN
- CS-045
- rezulin
- romglizone
- Troglitazona
- CI-991
- GR-92132X
- GR92132X
- Prelay
- Rezulin
- Romozin
- Noscal
- Resulin
- Romglizone
- Troglitazonum
- Parke Davis brand of troglitazone
- Resulin (TN)
- Rezulin (TN)
- Romozin (TN)
- Warner-Lambert brand of troglitazone
- Troglitazone [USAN:BAN:INN]
- Troglitazone (JAN/USAN/INN)
- CS 045
- troglitazona
- troglitazonum
- CI 991
- GR 92132X
- CHEBI:9753
- CS045
- I66ZZ0ZN0E
- DTXCID603719
- RefChem:56538
- A10BG01
- CCRIS 8969
- MFCD00878416
- Troglitazone (CS-045)
- NCGC00164445-01
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