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FLUMAZENIL
SynDRA canonical compound SYN0000045 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | GABRQ |
|---|
| Mechanism of action | Benzodiazepine receptor antagonist |
|---|
| Indication | sedative |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- GABRA3
- GABRA5
- GABRA2
- GABRA1
- GABRA4
- GABRA6
- GABRG3
- GABRG1
- GABRQ
- GABRP
- GABRG2
- GABRE
Mechanisms of action (all sources)
- Benzodiazepine receptor antagonist
- GABRA1 ALLOSTERIC ANTAGONIST
- GABRB2 ALLOSTERIC ANTAGONIST
- GABRG2 ALLOSTERIC ANTAGONIST
- GABRB3 ALLOSTERIC ANTAGONIST
- GABRA4 ALLOSTERIC ANTAGONIST
- GABRG3 ALLOSTERIC ANTAGONIST
- GABRQ ALLOSTERIC ANTAGONIST
- GABRA3 ALLOSTERIC ANTAGONIST
- GABRP ALLOSTERIC ANTAGONIST
- GABRD ALLOSTERIC ANTAGONIST
- GABRG1 ALLOSTERIC ANTAGONIST
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCB1
- MMP9
- MBNL1
- MC3R
- MC4R
- MC5R
- MLNR
- MMP1
- MPG
- MAPK3
- NEIL1
- NEIL2
- NFE2L2
- NPY1R
- NPY2R
- NR1I2
- MBD4
- MAPK14
- GPR119
- HTR2A
- HDAC6
- HMGCR
- HRH1
- HRH2
- HRH3
- HTR1A
- HTR2B
- MAPK1
- HTR2C
- HTR3A
- HTR6
- KCNH2
- LCK
- MAOA
- NR3C1
- NTHL1
- OGG1
- TACR2
- SLC6A2
- SLC6A3
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
- CP1A2
- CP2C9
- CP2CJ
- E2AK3
- IL1B
- PRGR
Drug classes
- Antidotes
- GABA Agents
- GABA Modulators
- Neurotransmitter Agents
- Protective Agents
- Benzodiazepine Antagonist
ATC classes
- V03A · ALL OTHER THERAPEUTIC PRODUCTS
Cross-references
Synonyms
- ROMAZICON
- anexate
- flumazepil
- mazicon
- Ro-15-1788
- Flumazepil
- Lanexat
- Mazicon
- NSC-759193
- RO-15-1788/000
- RO-15-1788
- RO-151788
- RO-151788000
- RO-1722
- RO-41-8157
- Anexate
- Romazicon
- Flumazenilum
- Flumazenilo
- Flumazenilum [Latin]
- Flumazenilo [Spanish]
- [11C]flumazenil
- Ro 151788
- Flumazenil (Ro 15-1788)
- UNII-40P7XK9392
- C15H14FN3O3
- CHEMBL407
- Ro15-1788
- BRN 4763661
- MLS000028850
- CHEBI:5103
- OFBIFZUFASYYRE-UHFFFAOYSA-N
- FlumUP TD
- Flumazenil (transdermal patch formulation)
- Flumazenil (transdermal patch formulation), Coeruleus
- NSC 759193
- flumazenil (usp-rs)
Reported adverse events
- Fear
- Death
- Arrhythmia
- Speech disorder
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