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ISOSORBIDE DINITRATE
SynDRA canonical compound SYN0000038 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | GUCY1B1 |
|---|
| Mechanism of action | Guanylate cyclase stimulant |
|---|
| Indication | angina pectoris | coronary artery disease (CAD) |
|---|
| Disease area | cardiology |
|---|
All known targets
- GUCY1A1
- GUCY1B1
- GUCY1A2
- GUCY1B2
- NPR1
- EGFR
- ESR1
Mechanisms of action (all sources)
- Nitric oxide stimulant
- Guanylate cyclase stimulant
- GUCY1B1 ACTIVATOR
- GUCY1A2 ACTIVATOR
- GUCY1A1 ACTIVATOR
- GUCY1B2 ACTIVATOR
- EGFR ACTIVATOR
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ACHE
- ADORA3
- SLCO1B3
- SLCO1B1
- SLC6A4
- SLC6A3
- SLC6A2
- PTH1R
- PTGS1
- PGR
- PDE4A
- PDE3A
- OPRM1
- MAOA
- KDR
- KCNH2
- HTR2B
- HTR1A
- HRH3
- HDAC6
- F2
- ESR1
- DRD3
- DRD1
- CHRM2
- CHRM1
- AR
- ADRA2A
- ADRA1A
- TBXA2R
Drug classes
- Nitrate Vasodilator
- Cardiovascular Agents
- Nitric Oxide Donors
- Vasodilator Agents
- Explosive Agents
- Anti-Asthmatic Agents
- Antioxidants
- Bronchodilator Agents
- Endothelium-Dependent Relaxing Factors
- Free Radical Scavengers
- Gasotransmitters
- Neurotransmitter Agents
ATC classes
- C05A · AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
- C01D · VASODILATORS USED IN CARDIAC DISEASES
- R07A · OTHER RESPIRATORY SYSTEM PRODUCTS
Cross-references
Synonyms
- BIDIL
- Bidil
- DILATRATE-SR
- ISORDIL
- ISOSORBIDE DINITRATE AND HYDRALAZINE HYDROCHLORIDE
- Isochron
- Isordil
- SORBITRATE
- r-isosorbide dinitrate
- vascardin
- astridine
- Dinitrate d'isosorbide
- Dinitrato de isosorbida
- Diluted isosorbide dinitrate
- Isomannide-dinitrate
- Isosorbide dinitrate, diluted-
- Isosorbidi dinitras dilutes
- Isosorbidi dinitras dilutus
- Sorbide nitrate
- C01DA08
- NSC-80038
- Angitak
- Carvasin
- Cedocard
- Cedocard ret
- Cedocard-10
- Cedocard-20
- Cedocard-40
- Cedocard-5
- Dilatrate
- Dilatrate-sr
- Imtack
- Iso mack
- Isocard
- Isoket 10
- Isoket 20
- Isoket 5
Reported adverse events
- Headache
- Vertigo
- Hypotension
- Syncope
- Palpitations
- Vomiting
- Nausea
- Tinnitus
- Abdominal discomfort
- Amblyopia
- Asthenia
- Chromaturia
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