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NICOTINE
SynDRA canonical compound SYN0000005 — structure-anchored drug synonym record
| Clinical phase | Launched |
|---|
| Approval status | Approved · Rx/OTC |
|---|
| Primary target(s) | CHRNA10 |
|---|
| Mechanism of action | Acetylcholine receptor agonist |
|---|
| Indication | smoking cessation |
|---|
| Disease area | neurology/psychiatry |
|---|
All known targets
- CHRNA4
- CHRNB2
- CHRNA9
- CHRNA10
- CHRNA2
- CHRNA3
- CHRNA6
- CHRNA7
- TRPA1
- CHRNB3
- CHRNB4
- Chrnb4
Mechanisms of action (all sources)
- Acetylcholine receptor agonist
- CHRNB2 AGONIST
- Neuronal acetylcholine receptor; alpha4/beta2 agonist
- CHRNA4 AGONIST
- nicotinic receptor agonist
Bioactivity evidence (ChEMBL activities table — not curator-asserted)
- ABCC2
- HTR2C
- PDE4A
- PDE3A
- OPRM1
- OPRK1
- OPRD1
- OGG1
- NTHL1
- NR3C1
- NPY2R
- NPY1R
- NFE2L2
- NEIL2
- NEIL1
- MMP9
- MMP1
- MC5R
- MC4R
- MC3R
- MBD4
- MAPT
- MAPK3
- MAPK14
- MAPK1
- MAOA
- LCK
- KDR
- KDM4E
- KDM4A
- KCNH2
- PDE5A
- PGR
- POLI
- SLC6A2
- UNG
- TDP1
- TDG
- TBXA2R
- TARDBP
Screening evidence (raw PubChem HTS — uncurated, known false-positive rate)
Drug classes
- Cholinergic Agents
- Cholinergic Agonists
- Ganglionic Stimulants
- Neurotransmitter Agents
- Nicotinic Agonists
- Peripheral Nervous System Agents
- Smoking Cessation Agents
- Cholinergic Nicotinic Agonist
ATC classes
- N07B · DRUGS USED IN ADDICTIVE DISORDERS
Cross-references
Synonyms
- Exodus
- HABITROL
- Habitrol
- NICODERM CQ
- NICORETTE
- NICORETTE (MINT)
- NICOTINE POLACRILEX
- NICOTROL
- Nicorelief
- Nicorette
- Nicotrol
- L-Nicotine
- (S)-Nicotine
- (-)-Nicotine
- nicotine bitartrate anhydrous
- nicotine polacrilex
- Nicabate
- Nicoderm cq
- Nicopass
- Nicopatch
- Nicorette invisi
- Nicotinell classic
- Nicotinell support
- Nicotinell tts 10
- Nicotinell tts 20
- Nicotinell tts 30
- Nicotrol inhaler
- Nicotrol ns
- Niquitin
- Niquitin clr
- Niquitin minis cherry
- Niquitin minis mint
- Niquitin minis orange
- Niquitin mint
- Niquitin pre-quit
- Niquitin strips mint
- Prostep
Reported adverse events
- Cough
- Anxiety
- Gastrointestinal disorder
- Adverse event
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